共查询到19条相似文献,搜索用时 124 毫秒
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肝素(heparin)是由肥大细胞产生的内源性分子,是一种高度硫酸化的糖胺聚糖,随着肥大细胞脱颗粒与组胺等物质一起释放到细胞外基质中。因其主要与抗凝血酶III结合而增强其活性,间接发挥抗凝作用,故在临床上作为抗凝剂广泛使用。然而,肝素在体内的主要生物学功能仍不清楚。研究表明,肝素能够结合体内多种蛋白,影响许多生物信息的传递,在肥大细胞活性、炎症反应、细胞增殖分化及多种疾病中发挥重要作用。本文总结肝素研究的重要成果,对肝素的主要的生物学功能进行综述。 相似文献
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《微生物学免疫学进展》2017,(1)
自从Paul Ehrlich于1878年首次发现肥大细胞以来,肥大细胞作为过敏反应中非常重要的效应细胞之一被广泛研究。直到近20年,人们才逐渐认识到肥大细胞参与多种病理、生理过程,尤其是在机体抗感染、免疫与免疫病理损伤中也发挥着重要作用。随着人们对肥大细胞在细菌和寄生虫的抗感染、免疫中作用的理解不断深入,肥大细胞在病毒感染及病毒引起的相关疾病中的作用逐渐成为备受关注的研究热点,现就肥大细胞在不同病毒感染中的作用作一综述。 相似文献
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动脉粥样硬化与清道夫受体研究进展 总被引:1,自引:0,他引:1
动脉粥样硬化是最重大的疾病之一,是心脑血管病的主要病理基础,严重危害人类健康.近年来的研究表明,清道夫受体在胆固醇代谢中起着重要作用.清道夫受体是一类结构多样化的糖蛋白受体,具有广泛的配体谱和功能.已知清道夫受体与动脉粥样硬化、宿主防御、细胞粘附、细胞增殖以及细胞凋亡等均有不同程度的关系.文章就近几年来有关该受体的结构、分布、表达调控及其在动脉粥样硬化中作用作一综述,以探索防治途径. 相似文献
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肥大细胞(mast cells)起源于骨髓造血干细胞,定植到机体各个外周组织后继续发育成熟,在过敏性反应和预防微生物感染等方面发挥重要作用。近来研究发现,肥胖患者的脂肪组织含有大量肥大细胞,引发人们对脂肪组织中肥大细胞作用的关注。肥大细胞可释放出多种生物活性介质,作用于脂肪组织,影响脂肪组织中细胞外基质的重塑和各种炎性细胞的活动。更多研究还表明肥大细胞可能参与到肥胖、糖尿病等代谢性疾病的发病机理,影响疾病的进展。本文总结近年来对脂肪组织中肥大细胞研究的一系列成果,对肥大细胞在脂肪组织中的生物学作用进行综述。 相似文献
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Mast cell function and dysregulation is important in the development and progression of allergic and autoimmune disease. Identifying novel proteins involved in mast cell function and disease progression is the first step in the design of new therapeutic strategies. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a family of proteins demonstrated to mediate the transport and fusion of secretory vesicles to the membrane in mast cells, leading to the subsequent release of the vesicle cargo through an exocytotic mechanism. The functional role[s] of specific SNARE family member complexes in mast cell degranulation has not been fully elucidated. Here, we review recent and historical data on the expression, formation and localization of various SNARE proteins and their complexes in murine and human mast cells. We summarize the functional data identifying the key SNARE family members that appear to participate in mast cell degranulation. Furthermore, we discuss the utilization of RNA interference (RNAi) methods to validate SNARE function and the use of siRNA as a therapeutic approach to the treatment of inflammatory disease. These studies provide an overview of the specific SNARE proteins and complexes that serve as novel targets for the development of new therapies to treat allergic and autoimmune disease. 相似文献
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Among the potential outcomes of an aberrantly functioning immune system are allergic disease and autoimmunity. Although it has been assumed that the underlying mechanisms mediating these conditions are completely different, recent evidence shows that mast cells provide a common link. Mast cells reside in most tissues, are particularly prevalent at sites of Ag entry, and act as sentinel cells of the immune system. They express many inflammatory mediators that affect both innate and adaptive cellular function. They contribute to pathologic allergic inflammation but also serve an important protective role in bacterial and parasite infections. Given the proinflammatory nature of autoimmune responses, it is not surprising that studies using murine models of autoimmunity clearly implicate mast cells in the initiation and/or progression of autoimmune disease. In this review, we discuss the defined and hypothesized mechanisms of mast cell influence on autoimmune diseases, including their surprising and newly discovered role as anti-inflammatory cells. 相似文献
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Human atherosclerosis has many characteristics of an inflammatory disorder. Recent data suggest that mast cells might be important in the pathogenesis of atherosclerotic disease. By secretion of pro-inflammatory cytokines, mast cells can assist in the recruitment of monocytes and lymphocytes into vascular tissue, thereby propagating the inflammatory response. Mast cell enzymes might activate pro-metalloproteinases, thereby destabilizing atheromatous plaques. Mast cells can facilitate foam cell formation by promoting cholesterol accumulation. However, mast cell tryptase could slow thrombus formation at sites of plaque rupture by interfering with coagulation. Therefore, mast cells can modulate coronary artery disease by both facilitatory and inhibitory pathways. 相似文献
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肥大细胞是人体主要免疫细胞之一,因其作为导致过敏反应发生的最直接效应细胞而著称.肥大细胞最主要的结构特征为其胞内含有大量嗜碱性颗粒,该颗粒内又富含种类众多的生物活性物质,包括组胺、血管内皮生长因子(vascular endothelial growth factor,VEGF)、成纤维细胞生长因子(fibroblast... 相似文献
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Tumor cells are surrounded by infiltrating inflammatory cells, such as lymphocytes, neutrophils, macrophages, and mast cells. A body of evidence indicates that mast cells are associated with various types of tumors. Although role of mast cells can be directly related to their granule content, their function in angiogenesis and tumor progression remains obscure. This study aims to understand the role of mast cells in these processes. Tumors were chemically induced in BALB/c mice and tumor progression was divided into Phases I, II and III. Phase I tumors exhibited a large number of mast cells, which increased in phase II and remained unchanged in phase III. The expression of mouse mast cell protease (mMCP)-4, mMCP-5, mMCP-6, mMCP-7, and carboxypeptidase A were analyzed at the 3 stages. Our results show that with the exception of mMCP-4 expression of these mast cell chymase (mMCP-5), tryptases (mMCP-6 and 7), and carboxypeptidase A (mMC-CPA) increased during tumor progression. Chymase and tryptase activity increased at all stages of tumor progression whereas the number of mast cells remained constant from phase II to III. The number of new blood vessels increased significantly in phase I, while in phases II and III an enlargement of existing blood vessels occurred. In vitro, mMCP-6 and 7 are able to induce vessel formation. The present study suggests that mast cells are involved in induction of angiogenesis in the early stages of tumor development and in modulating blood vessel growth in the later stages of tumor progression. 相似文献
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c-Fos as a regulator of degranulation and cytokine production in FcepsilonRI-activated mast cells 总被引:3,自引:0,他引:3
Lee YN Tuckerman J Nechushtan H Schutz G Razin E Angel P 《Journal of immunology (Baltimore, Md. : 1950)》2004,173(4):2571-2577
The AP-1 complex is composed of c-Jun and c-Fos and is a key component in the regulation of proinflammatory genes. Mast cells play a significant role in the initiation of many inflammatory responses, such as allergy and allergy-associated diseases. In the present work, we characterized the role of c-Fos in mast cell function by investigating IL-3-dependent cell proliferation, degranulation capability, and cytokine expression in c-Fos-deficient mice. In c-Fos-deficient mast cells, we found that FcepsilonRI-mediated degranulation was significantly inhibited, which correlates with the reduced expression of SWAP-70, VAMP-7, and Synaptotagmin I genes, which are involved directly in the degranulation process. These findings show that c-Fos plays an important role in FcepsilonRI-mediated regulation of mast cell function. 相似文献
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Mast cell degranulation can initiate an acute inflammatory response and contribute to the progression of chronic diseases. Alteration in the cellular programs that determine the requirement for mast cell degranulation would therefore have the potential to dramatically impact disease severity. Mast cells are exposed to increased levels of PGE2 during inflammation. We show that although PGE2 does not trigger the degranulation of dermal mast cells of young animals, in older mice, PGE2 is a potent mast cell stimulator. Intradermal administration of PGE2 leads to an EP3 receptor-dependent degranulation of mast cells, with the number of degranulated cells approaching levels observed in IgE- and Ag-treated controls. Taken together, these studies suggest that the ability of PGE2 to initiate mast cell degranulation changes in the aging animal. Therefore, elevated PGE2 levels might provide an important pathway by which mast cells are engaged to participate in inflammatory responses in the elderly patient. 相似文献
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Atherosclerosis is a pathologic process occurring within the artery, in which many cell types, including T cell, macrophages, endothelial cells, and smooth muscle cells, interact, and cause chronic inflammation, in response to various inner- or outer-cellular stimuli. Atherosclerosis is characterized by a complex interaction of inflammation, lipid deposition, vascular smooth muscle cell proliferation, endothelial dysfunction, and extracellular matrix remodeling, which will result in the formation of an intimal plaque. Although the regulation and function of vascular smooth muscle cells are important in the progression of atherosclerosis, the roles of smooth muscle cells in regulating vascular inflammation are rarely focused upon, compared to those of endothelial cells or inflammatory cells. Therefore, in this review, we will discuss here how smooth muscle cells contribute or regulate the inflammatory reaction in the progression of atherosclerosis, especially in the context of the activation of various membrane receptors, and how they may regulate vascular inflammation. [BMB Reports 2014; 47(1): 1-7] 相似文献