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The presence of supercoiled deoxyribonucleic acid in the form of a relaxation complex is described for the antibiotic resistance plasmids R64, R28K, and R6K. The properties of these relaxation complexes indicate that they consist of a covalently closed circular deoxyribonucleic acid molecule associated with an activable, single strand-specific endonuclease.  相似文献   

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Michael Friendly 《Biometrics》2011,67(3):1177-1177
Graphics for Statistics and Data Analysis with R (K. J. Keen) Michael Friendly Hidden Markov Models for Time Series: An Introduction Using R (W. Zucchini and I. L. MacDonald) Peter Guttorp Bayesian Adaptive Methods for Clinical Trials (S. M. Berry, B. P. Carlin, J. J. Lee, J. J. and P. Muller) Say Beng Tan SAS and R Data Management, Statistical Analysis, and Graphics (K. Kleinman and N. Horton) Juan P. Steibel Numerical Analysis for Statisticians, 2nd edition (K. Lange) Maria Rizzo Statistical Methods for Disease Clustering (T. Tango) Lance A. Waller Brief Reports by the Editor Survival Analysis Using SAS: A Practical Guide (P. D. Allison) Design and Analysis of Quality of Life Studies in Clinical Trials (D. L. Fairclough) Nonparametric Statistical Inference (J. D. Gibbons and S. Chakraborti) Stochastic Processes: An Introduction (P. W Jones and P. Smith)
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