耳穴疗法联合刮痧在糖尿病周围神经病变中的应用

目的探讨耳穴疗法联合虎符铜砭刮痧在糖尿病周围神经病变中的应用效果。方法选择2019年5～12月我院就诊的2型糖尿病合并周围神经病变患者75例,随机分为对照组37例和观察组38例。对照组给予甲钴胺注射液治疗,同时采用糖尿病护理常规及糖尿病周围神经病变常规护理措施;观察组在对照组的基础上给予耳穴疗法(取耳穴:内分泌、皮质下、迷走神经、胰、神门、交感)联合虎符铜砭刮痧治疗。观察比较两组患者治疗前后血糖水平[空腹静脉血糖(FPG)和餐后2 h血糖(2h-PG)]、Toronto临床系统评分(TCSS)、神经传导速度(NCV)评分[包括正中神经和腓总神经的运动神经传导速度(MNCV)和感觉神经传导速度(SNCV)]。结果观察组治疗前后的FPG、2h-PG、TCSS、MNCV、SNCV评分比较,差异有统计学意义(均P0.05);对照组治疗前后FPG、2h-PG、TCSS、MNCV、SNCV评分比较,差异无统计学意义(均P0.05)。两组治疗后的FPG、2h-PG、TCSS、MNCV、SNCV评分比较,差异具有统计学意义(均P0.05)。结论耳穴疗法联合虎符铜砭刮痧对调节糖尿病周围神经病变患者的血糖水平、控制神经症状、提高神经传导速度的疗效确切,能促进机体康复。     

降纤酶联合甲钴胺治疗糖尿病周围神经病变的研究

目的 观察降纤酶联合甲钴胺治疗糖尿病周围神经病变的临床疗效.方法 选择60例糖尿病合并周围神经病变患者,随机分成治疗组和对照组各30例,治疗组用降纤酶首次剂量为10 u,第2天后改为5 u,每天1次,连续2周;同时应用甲钴胺500 μg肌肉注射,每天1次,连续2周.对照组用甲钴胺500 μg肌肉注射,每天1次,连续2周.两组进行疗效比较.结果 治疗2周后两组神经症状与检查评分均明显下降,但以治疗组下降显著,治疗后两组平均评分差异有统计学意义(P＜0.01).结论 降纤酶联合甲钴胺治疗糖尿病周围神经病变有较好的疗效.     

光子中医信息疗法治疗糖尿病周围神经病变的临床研究

目的:观察光子中医信息疗法对糖尿病周围神经病变患者的临床疗效。方法:将60例符合入选标准的患者,以1∶1的比例随机分配到治疗组(光子中医信息疗法联合药物组)、对照组(药物组),两组患者均给予糖尿病基础治疗,对照组加甲钴胺口服,每次500μg,每日3次,疗程4周;治疗组在对照组的基础上配合光子中医信息疗法,隔日照射1次,每周3次,6次为1疗程,共2个疗程。治疗前后分别对两组患者的中医临床症状、神经症状体征进行评定,并测定周围神经传导速度及观察血糖变化情况,进行综合疗效评估。结果:治疗组的临床综合疗效明显优于对照组,两组的总有效率比较有显著性差异(P<0.05)。治疗组在中医症状改善、周围神经症状及体征改善、提高周围神经传导速度方面均优于对照组,组间比较均具有显著性差异(P<0.05)。治疗后治疗组空腹血糖、餐后血糖、糖化血红蛋白与治疗前比较均明显降低(P<0.01),对照组治疗前后比较及治疗后组间比较均无显著性差异(P>0.05)。结论:光子中医信息疗法联合药物组相对于药物组在改善DPN患者的临床症状、周围神经症状及体征、神经的传导速度等方面均有良好的优势,同时具有一定的辅助降糖趋势。     

定期血糖监测对糖尿病患者血糖控制及生活方式的影响

目的:探讨定期血糖监测对糖尿病血糖控制及生活方式的影响。方法:随机抽取我中心2010-2011年度确诊的老年2型糖尿病患者110例,随机分为干预组和对照组,每组各55例;2组均接受正规降糖药物治疗及生活方式指导,干预组每周进行一次血糖监测,每3个月测一次糖化血红蛋白,对照组按患者意愿测定血糖指标,通过12个月的观察,研究两组患者在血糖控制及生活方式上的差异。结果:干预组患者空腹血糖(FPG)由定期监测血糖前的(7.26±1.36)mmol/L降至(6.68±1.10)mmol/L;餐后2小时血糖(2HPG)由定期监测血糖前的(12.34±2.29)mmol/L降至(11.09±1.98)mmol/L;糖化血红蛋白由监测前的(7.99±1.61)%降至(6.60±0.87)%;差异具有显著性(P<0.05);生活方式亦有明显改善,差异具有显著性(P<0.05);而对照组的改变不如干预组。结论:通过定期血糖监测可以有效地控制血糖、糖化血红蛋白,促使老年2型糖尿病患者改变不良生活方式。     

大黄蛰虫汤加减联合甲钴胺治疗糖尿病周围神经病变的临床观察

目的观察大黄蛰虫汤加减治疗糖尿病周围神经病变的临床疗效。方法将60例糖尿病周围神经病变患者随机分为2组。治疗组30例予大黄蜇虫汤(大黄、黄芩、芍药、生地、桃仁、杏仁、水蛭、土鳖虫等)加减联合甲钴胺治疗,对照组30例予甲钴胺治疗。2组均30 d为1个疗程。观察自觉症状,腱、膝反射,神经传递速度等。结果治疗组:总有效率86.7%,对照组70.0%,两组比较差异有统计学意义(P0.05)。结论大黄蜇虫汤加减治疗糖尿病周围神经病变不仅能改善临床症状,而且对神经传递方面有显著改善,疗效确切。     

短期胰岛素泵强化治疗对2型糖尿病患者血脂血糖水平的影响

目的:探讨短期胰岛素泵强化治疗对2型糖尿病患者血脂血糖代谢的影响。方法:选取76例2型糖尿病患者,按给药方式不同分为两组,对照组(38例)给予门冬胰岛素常规治疗,观察组(38例)给予胰岛素泵强化治疗,依据两组治疗前后的血糖、血脂指标变化及治疗前、治疗后1周、2周的ADL量表评分评价短期胰岛素泵强化治疗对2型糖尿病患者血脂血糖代谢的影响。结果:治疗后,两组患者的空腹血糖(FPG)、糖化血红蛋白(Hb Alc)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平均较治疗前显著降低,高密度脂蛋白胆固醇(HDL-C)水平均明显升高,且观察组FPG、Hb Alc、TC、TG、LDL-C水平均明显低于对照组,HDL-C水平显著高于对照组(P0.05)。治疗后1周、2周,两组ADL评分均较治疗前明显提高,且观察组显著高于对照组(P0.05)。结论:短期胰岛素泵强化治疗能显著改善2型糖尿病患者的血糖血脂代谢紊乱,并提高患者的日常生活能力。     

鼠神经生长因子对2型糖尿病周围神经病变的影响

目的:探讨鼠神经生长因子治疗2型糖尿病周围神经病变(DPN)临床疗效及安全性。方法:选择89例DPN患者分为观察组45例和对照组44例,两组都给予糖尿病的基础治疗,观察组在基础治疗基础上,加用注射用鼠神经生长因子,对照组加用甲钴胺注射液和丹红注射用,治疗前后测定正中神经和腓总神经的感觉传导速度(SNCV)、运动传导速度(MNCV),行多伦多临床评分系统(TCSS)评分。结果:治疗前,两组患者TCSS评分、正中神经、腓总神经的MNCV及SNCV相似,差异无统计学意义(P0.05);疗程结束时,两组TCSS评分较治疗前均下降,正中神经、腓总神经的MNCV及SNCV较治疗前均增加,差异有统计学意义(P0.05),但是观察组改善幅度较对照组更显著(P0.05)。观察组显效20例、有效23例和无效2例;对照组显效15例、有效21例和无效8例,差异有统计学意义(P0.05)。两组患者治疗期间未见严重不良反应发生。结论:加用鼠神经生长因子可以有效缓解2型糖尿病DPN的临床症状,提高神经传导速度,安全性高。     

中西医结合治疗老年2型糖尿病合并高血脂疗效观察

目的观察中西医结合治疗老年2型糖尿病合并高脂血症的疗效。方法选择2011年10月~2014年10月经我院内科门诊诊断为2型糖尿病合并高脂血症患者80例,随机分为观察组和对照组各40例。对照组给予口服罗格列酮加二甲双胍治疗,观察组在对照组基础上加用中药消渴汤加减口服。两组均4周为1疗程,治疗2个疗程观察比较两组临床治疗效果和空腹血糖(FPG)、糖化血红蛋白(HbA1c)和血脂各项指标变化情况。结果观察组治疗总有效率90.00%,对照组为70%,两组疗效比较差异有统计学意义(P0.01)。两组空腹血糖(FPG)、糖化血红蛋白(HbA1c)、血脂各项指标与治疗前比较,差异有统计学意义(P0.01));治疗后两组比较,治疗组下降率明显优于对照组(P0.01)。结论采用中西医结合治疗老年2型糖尿病合并高脂血症能有效控制血糖水平,降低血脂,而且安全、简便,是治疗糖尿病及其慢性微血管并发症的有效方法。     

每日2次和3次皮下注射诺和锐30疗效临床分析

目的:比较诺和锐30每日2次和3次皮下注射的疗效和安全性。方法:为期3个月的随机、开放式试验,100例2型糖尿病(T2DM)患者随机分为诺和锐30皮下注射2次(每日早、晚餐前)、3次(早、中、晚餐前)组,观测两组患者空腹血糖(FPG),中餐前血糖,晚餐前血糖,睡前的血糖值以及糖化血红蛋白(HbA1c),低血糖事件及其他不良事件差异。结果:诺和锐30皮下注射3次组总体血糖水平低于2次组,低血糖事件和其他不良反应发生次数无显著性差异。结论:两组治疗方法均能有效地降低血糖,3次治疗组控制餐后血糖更具优势,HbA1c降低更好,未增加低血糖风险。     

降纤疗法治疗血液高粘滞综合征180例

我院应用降纤酶治疗高粘滞综合征 1 80例 ,疗效满意 ,现报告如下。1　临床资料1 .1　一般资料　本组 1 80例中 ,男 1 0 6例 ,女 74例 ;1 8～ 30岁 1 1例 ,31～ 40岁 30例 ,41～ 50岁65岁 ,51岁以上 74例 ;单纯高粘滞血症 83例 ,合并高血脂症 37例 ,冠心病 31例 ,脑血管破裂或脑血栓后遗症 1 9例 ,脉管炎 4例 ,糖尿病 6例。1 .2　治疗方法　用降纤酶 5u加入生理盐水1 50 ml中静滴 ,1 h内滴完。每天 1次 ,1 5天为 1疗程。隔 1 5天后再用第 2个疗程。用前作皮试 ,阴性者用药。全部病例治疗前及治疗后 1个月随访检查血脂、血糖、血细胞、心电图…     

六种藓类植物茎的比较解剖学研究

通过对6种藓类植物,即褶叶青藓(Brachythecium salebrosum(Web.et Mohr.)B.S.G.)、湿地匐灯藓(Plagiomnium acutum(Lindb.)Kop.)、侧枝匐灯藓(Plagiomnium maximoviczii(Lindb.)Kop.)、大凤尾藓(Fissidensnobilis Griff.)、大羽藓(Thuidium cymbifolium(Doz.et Molk.)B.S.G.)和大灰藓(Hypnum plumaeforme Wils.)嫩茎和老茎的石蜡切片和显微观察发现,同一藓类植株的嫩茎和老茎,茎结构稳定,不同种藓类植物茎横切面具有不同特征.植物体茎横切面形状、表层细胞的层数、细胞大小和细胞壁厚薄、皮层细胞大小和形状、中轴的有无以及比例等特征可以作为藓类植物的分科分类依据之一.     

Photoregulation of seed germination of wild-type and of an aurea-mutant of tomato

Seed germination of an aurea mutant of tomato ( Lycopersicon esculentum Mill.) is promoted by continuous irradiation with red, far-red or long-wavelength far-red (758 nm) light as well as by cyclic irradiations (5 min red or 5 min far-red/25 min darkness). Far-red light applied immediately after each red does not change the germination behaviour. Seed germination of the isogenic wild-type, cv. UC-105, is promoted by continuous and cyclic red light while it is inhibited by continuous and cyclic far-red light and by continious 758 nm irradiation. Far-red irradiation reverses almost completely the promoting effect of red light. The promoting effect (in the aurea mutant) and the inhibitory effect (in the wild-type) of continuous far-red light do not show photon fluence rate dependency above 20 nmol m⁻² s⁻¹. It is concluded that phytochrome controls tomato seed germination throgh low energy responses in both the wild type and the au mutant. The promoting effect of continuous and cyclic far-red light in the au mutant can be attributed to a greater sensitivity to P_fr.     

Cause of Senescence of Nine Sorts of Flowers

The levels of endogenous phytohormones and respiratory rate in nine sorts of flowers such as Cymbidium faberi Rolfe, Nopalxochia ackermannii Kunth and others were investigated both at full bloom and senescence and meanwhile the effect of exogenous phytohormones on prolonging the blossoms and promoting ethylene production were tested. There is a high content of endogenous ethylene in all the long-lived flowere, about 3–16 folds higer than the short-lived ones. There is a high level of ABA at full blooming flowers of short-lived flowers, in which there is no or only some cytokinins in it, but the ratio of CTK (6BA+zeatin)/ABA is smaller(l.7). The endogenous ABA reached a much higher level at senescence in all nine sorts of flowers, so it is reasonable to consider that it is ABA which plays an important role of regulation in controlling flower's senescence. There is a much higher level of GA3 and zeatin in the long-lived flowers which is not demonstrated in the shortlived ones. The respiratory rate is one of the factors controtling the longevity of flowers, but it does not play a decided role. Application of 6BA and zeatin prolongs distinctly orchid’s longevity, however exogenous IAA through the promotive action on ethylene production, evidently extends the longevity of the flowers of the Nopalxochia ackermannii Kunth.     

真菌类遗传学分析的知识结构教学

本文以认知结构理论为指导,讨论了真菌类遗传分析与高等动植物遗传分析的内在联系,认为利用这种内在联系进行教学可收到好的效果并说明了作者的具体教学过程。 Abstract:In the paper, the relationship between genetic analysis of Fungi and genetic analysis of high animal and plant was discussed.A good results were obtained when we adopted this method in the teaching.     

龙胆科药用植物化学成分的研究现状

龙胆科植物在我国的分布范围很广,且多数为药用植物,其多数种属的药用植物,至今其化学成分尚未被系统研究。综述了目前龙胆科药用植物的化学成分的研究现状及一般提取方法,对近年来发现的环烯醚萜及裂环烯醚萜类化合物进行了总结,为本科药用植物的更深入研究提供了参考。     

Interconnection of parameters of regulation system of lipid peroxidation and of morphophysiological parameters of mouse liver

A complex analysis of seasonal fluctuations of the mean group parameters of the system of regulation of lipid peroxidation has been performed in liver of Balb/c mice. Association of lipid characteristics and morphophysiological parameters is studied in the Balb/c mouse liver. An inter-connection is revealed between the liver index and the amount of lysoforms of phospholipids, the scale and character of the interconnection differing essentially depending on proportion of phos-phatidylcholine in mouse liver phospholipids.     

The effects of glutamine of the maintenance of embryogenic cultures of Cryptomeria japonica

Summary Embryogenic tissues of sugi (Cryptomeria japonica) were induced on a modified Campbell and Durzan (CD) medium containing 1 μM 2,4-dichlorophenoxyacetic acid (2,4-D) and 600 mg l⁻¹ glutamine, and subcultured in the medium of the same composition for over 1 yr. This resulted in a mixed culture of embryogenic and non-embryogenic cells. When embryogenic cells were isolated and cultured independently, their capacity to form embryogenic aggregates was lost. Thus, the non-embryogenic cells present within a mixed culture system were essential to the formation of embryogenic aggregates. When embryogenic tissues were isolated and cultured independently on a high glutamine-containing (2400 mg l⁻¹) medium, dry weights and endogenous levels of glutamine increased, and the tissue could generate a large number of embryogenic aggregates. Amino acid analysis of embryogenic and non-embryogenic cells from the maintenance culture indicated a higher level of glutamine was present in the latter. The high endogenous level of glutamine in the non-embryogenic portion of mixed cell masses may be the supplier of glutamine for maintaining the embryogenic property of the tissues.     

Specificity of action of piperidylcholine derivatives as substrates of cholinesterases of various origin

The review deals with study of enzymologic properties of a novel highly specific acetylcholinesterase substrate, N-(β-acetoxyethyl) piperidinium iodomethylate (“piperidylcholine”), and its 30 derivatives that were tested as effectors of cholinesterases of mammals and various species of Pacific squids. It was proven for the first time that responsible for specificity of action was structure of cyclic ammonium grouping of the alcohol part of molecule of the ester substrate. Analysis of specificity is performed based on enzymatic hydrolysis parameters—activity of catalytic center of cholinesterases and bimolecular constant of the reaction rate that are determined at optimal and low substrate concentrations. Among the specially synthesized group of thioester compounds there is revealed one more highly specific acetylcholinesterase substrate—N-(β-acetoxyethyl) piperidinium.