短期胰岛素泵强化治疗对2型糖尿病患者血脂血糖水平的影响

目的:探讨短期胰岛素泵强化治疗对2型糖尿病患者血脂血糖代谢的影响。方法:选取76例2型糖尿病患者,按给药方式不同分为两组,对照组(38例)给予门冬胰岛素常规治疗,观察组(38例)给予胰岛素泵强化治疗,依据两组治疗前后的血糖、血脂指标变化及治疗前、治疗后1周、2周的ADL量表评分评价短期胰岛素泵强化治疗对2型糖尿病患者血脂血糖代谢的影响。结果:治疗后,两组患者的空腹血糖(FPG)、糖化血红蛋白(Hb Alc)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平均较治疗前显著降低,高密度脂蛋白胆固醇(HDL-C)水平均明显升高,且观察组FPG、Hb Alc、TC、TG、LDL-C水平均明显低于对照组,HDL-C水平显著高于对照组(P0.05)。治疗后1周、2周,两组ADL评分均较治疗前明显提高,且观察组显著高于对照组(P0.05)。结论:短期胰岛素泵强化治疗能显著改善2型糖尿病患者的血糖血脂代谢紊乱,并提高患者的日常生活能力。

Effect of Short-term Insulin Intensive Therapy on the Blood Glucose and Lipid Levels of Patients with Type 2 Diabetes

ABSTRACT Objective: To investigate the effect of short term and intensive insulin pump on the blood lipid and glucose levels of patients with type 2 diabetes. Methods: 76 patients with type 2 diabetes were selected and divided into two groups according to different administration. The control group (38 cases) was given routine insulin aspart treatment. The observation group (38 cases) was treated by insulin pump. The blood and lipid indexes and ADL score before treatment, at 1 week and 2 weeks after treatment were compared be- tween two groups. Results: After treatment, the levels of FPG, HbAlc, TC, TG and LDL-C were lower than those before treatment and the level of HDL-C was increased in both groups. The levels of FPG, HbAlc, TC, TG, LDL-C of observation group were lower than those of the control group, and the level of HDL-C of observation group was higher than that of control group (P<0.05). At 1 week, 2 weeks af- ter treatment, the ADL scores of both groups were significantly improved, and the ADL score of observation group was higher than that of the control group (P<0.05). Conclusion: Short term intensive insulin pump could significantly improve the blood glucose and lipid metabolism disorders in patients with type 2 diabetes, and improve the ability of daily life.