云南黑籽南瓜砧木对低温下嫁接黄瓜生理特性的影响

以‘津研4号’黄瓜(Cucumis sativus‘Jinyan No.4’)为接穗,云南黑籽南瓜(Cucurbita ficifoliaBouch啨)和黄瓜为砧木,研究了低温条件下黄瓜/云南黑籽南瓜嫁接株(黄瓜/南瓜)、黄瓜/黄瓜嫁接株和自根黄瓜株叶片的蔗糖(Suc)、葡萄糖(Glc)和可溶性蛋白质(Pr)含量的变化以及叶片羧化效率(CE)及不同叶位叶片、不同节位茎段中异戊烯基腺嘌呤核苷(iPA)含量的差异。结果表明,黄瓜/南瓜嫁接株叶片的Suc、Glc及Pr含量和CE值均显著高于自根黄瓜株和黄瓜/黄瓜嫁接株,自根黄瓜株与黄瓜/黄瓜嫁接株间差异不显著。iPA在嫁接植株和自根植株茎中均呈梯度分布,其含量在生长锥中最高,其次为上部茎段,下部茎段中的含量最低;自根黄瓜株和黄瓜/黄瓜嫁接株茎中的iPA含量显著低于黄瓜/南瓜嫁接株,而叶片中iPA含量显著高于黄瓜/南瓜嫁接株。研究结果表明,以黑籽南瓜为砧木可提高嫁接黄瓜对低温的耐受性。     

不同基因型砧木嫁接黄瓜结瓜盛期光合特性的比较

采用CIRAS-Ⅱ型便携式光合作用系统,对黑籽南瓜和新培育的白籽南瓜A22种不同基因型砧木嫁接黄瓜结瓜盛期的光合特性进行比较。结果表明：在结瓜盛期,2种砧木嫁接黄瓜不同叶位的叶片净光合速率均有一定差异,其中A2嫁接黄瓜中部和下部叶片的净光舍速率显著高于黑籽南瓜嫁接的黄瓜。A2与黑籽南瓜相比其嫁接黄瓜利用光能范围较广且光饱和时净光合速率、RuBP最大再生速率和表观量子效率分别高出黑籽南瓜嫁接的黄瓜23．2％、12．6％和8．2％。2种砧木嫁接的黄瓜CO2饱和点与羧化效率均相近,CO2补偿点A2低于黑籽南瓜嫁接的黄瓜。A2嫁接黄瓜叶片叶绿素a、b及叶绿素总量均明显高于黑籽南瓜嫁接的黄瓜,可溶性蛋白含量与黑籽南瓜嫁接的黄瓜差异不显著。A2嫁接黄瓜的雌花节率和平均单株产量分别高出黑籽南瓜嫁接的黄瓜25．2％和29．4％,A2嫁接黄瓜果实可溶性糖、可溶性蛋白和VC含量分别高出黑籽南瓜嫁接的黄瓜6.3％、15,2％和15．4％。     

NaCl胁迫对嫁接黄瓜膜脂过氧化、渗透调节物质含量及光合特性的影响

以日本引进的耐盐品种‘帝王新土佐’南瓜为砧木,以‘津研4号’黄瓜品种为接穗,研究了NaCl胁迫对黄瓜嫁接植株和自根植株的膜脂过氧化、渗透调节物质含量及光合特性的影响。结果表明:在NaCl胁迫下,黄瓜嫁接植株叶片超氧化物歧化酶(SOD)、过氧化物酶(POD)、过氧化氢酶(CAT)和抗坏血酸过氧化物酶(APX)活性均显著高于自根植株,O·2-产生速率及丙二醛(MDA)含量显著低于自根植株,嫁接植株膜脂过氧化轻于自根植株;嫁接植株叶片游离脯氨酸、可溶性糖、可溶性蛋白质等渗透物质含量均显著高于自根植株;嫁接植株的净光合速率(Pn)、气孔导度(Gs)、胞间CO2浓度(Ci)、叶绿素含量均显著高于自根植株;虽然NaCl胁迫抑制光合作用,但嫁接植株仍表现出优势。以上结果证明,嫁接植株耐盐性优于自根植株。     

环境条件对黄瓜硅吸收分配和果面蜡粉形成的影响

为探明环境条件影响黄瓜果面蜡粉形成的机制,以‘山农5号’黄瓜为接穗,‘黄诚根2号’南瓜(去蜡粉能力强)和‘云南黒籽南瓜’(去蜡粉能力弱)为砧木进行嫁接,在日光温室不同栽培茬口(冬春茬和秋冬茬)下研究了硅吸收分配和果面蜡粉量差异,并在人工气候室内模拟不同季节环境条件[T₁:温度28 ℃/18 ℃(昼/夜),相对湿度55%/65%,光照强度600 μmol·m^-2·s^-1;T₂:温度22 ℃/12 ℃(昼/夜),相对湿度85%/95%,光照强度300 μmol·m^-2·s^-1],研究其对硅吸收分配和硅转运蛋白基因表达的影响。结果表明:日光温室栽培条件下,与秋冬茬相比,冬春茬黄瓜商品成熟果实表面蜡粉量显著增加,其中以‘云南黑籽南瓜’嫁接黄瓜受影响较大,自根黄瓜和‘黄诚根2号’嫁接黄瓜受影响较小;相同栽培季节,均以‘云南黑籽南瓜’嫁接黄瓜果面蜡粉量和器官硅含量最多,自根黄瓜次之,‘黄诚根2号’嫁接黄瓜最少。人工气候室内,T₁环境下黄瓜各器官硅含量、叶片和根系硅转运蛋白基因表达量均高于T₂;相同环境条件下,黄瓜各器官硅含量和叶片硅转运蛋白基因表达量均为‘云南黑籽南瓜’嫁接黄瓜＞自根黄瓜＞‘黄诚根2号’嫁接黄瓜。综上,环境条件改变了黄瓜植株对硅的吸收分配,进而影响果面蜡粉形成,适宜的环境条件有利于减少果面蜡粉量;高温、强光、低湿环境导致黄瓜果面蜡粉量增多,砧木对嫁接黄瓜硅吸收和果面蜡粉形成有显著影响。     

氯化钠胁迫对嫁接黄瓜叶片多胺含量的影响

以日本耐盐品种‘帝王新土佐’南瓜为砧木,以’新泰密刺’黄瓜为接穗,在100 mmol·L^-1 NaCl胁迫下,对黄瓜嫁接和自根植株不同时期叶片中不同形态多胺含量的变化进行了研究.结果表明：NaCl胁迫下黄瓜嫁接植株游离态腐胺（Put）含量在胁迫2 d时与自根植株无显著差异,其余时间均显著高于自根植株;游离态亚精胺（Spd）和游离态精胺（Spm）含量在整个胁迫期间均显著高于自根植株;游离态多胺总量（PAs）在胁迫第4天出现峰值;嫁接植株游离态Put/PAs值在胁迫4 d时与自根植株无显著差异,其余胁迫时间均显著低于自根植株,而(Spd+Spm)/Put值在整个胁迫期间均显著高于自根植株;嫁接植株结合态和束缚态Put、Spd和Spm含量在整个胁迫期间均显著高于自根植株,结合态和束缚态PAs在胁迫第6天出现峰值;结合态多胺的Put/PAs值和(Spd+Spm)/Put值变化趋势与游离态多胺一致;嫁接植株束缚态Put/PAs值在胁迫6 d时与自根植株无显著差异,其余时间均显著低于自根植株,而(Spd+Spm)/Put值在整个胁迫期间均显著高于自根植株.表明黄瓜嫁接植株表现出较强的耐盐特征.     

不同抗性砧木嫁接黄瓜幼苗对NaCl胁迫的生理响应

在对系列黄瓜嫁接砧木进行耐盐性鉴定的基础上,选择夏尔巴、新土佐、铁力砧和云南黑籽南瓜4种抗性不同的砧木品种嫁接‘新泰密刺’黄瓜,以自根苗为对照,研究了幼苗对NaCl胁迫的生理响应差异.结果表明:在100 mmol·L-1 NaCl胁迫条件下,嫁接苗的电解质相对渗漏率和丙二醛含量均显著低于自根苗,其中黑籽南瓜嫁接苗最低,其次是铁力砧、新土佐和夏尔巴嫁接苗;NaCl胁迫下嫁接苗叶片中脯氨酸、可溶性糖含量及过氧化物酶(POD)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、抗坏血酸过氧化物酶(APX)活性均显著高于自根苗,其中黑籽南瓜嫁接苗最高,铁力砧和新土佐嫁接苗间无显著差异,夏尔巴嫁接苗最低.NaCl胁迫后,嫁接苗叶片中Na+含量为黑籽南瓜＜铁力砧＜新土佐＜夏尔巴＜自根苗,K+含量在黑籽南瓜、铁力砧和新土佐嫁接苗间差异不大,但均明显高于夏尔巴嫁接苗,自根苗含量最低;嫁接苗Na+/K+显著低于自根苗,以黑籽南瓜嫁接苗最低.     

嫁接对薄皮甜瓜养分吸收、伤流液中激素含量和产量的影响

以薄皮甜瓜品种‘玉美人’作接穗,以白籽南瓜‘圣砧一号’为砧木进行嫁接,以自根苗为对照的结果表明,嫁接植株的南瓜根系主动吸收能力增强,其伤流量比自根植株的大,植株吸收氮钾的能力高于自根植株,而吸收磷的能力则有所降低。伤流液中玉米素（ZT）、赤霉素（GAs）和脱落酸（ABA）的浓度均低于自根植株,但ZT和GA的含量高于自根苗,而ABA的含量低于自根苗。嫁接植株的增产效果显著,其平均单瓜重和667m^2产量均高于自根植株。     

NaCl胁迫对营养液栽培嫁接黄瓜生物量及离子分布的影响

以‘帝王新土佐’南瓜为砧木,以‘新泰密刺’黄瓜品种为接穗,在100 mmol.L-1NaCl胁迫下,对黄瓜嫁接和自根植株生物量及各器官离子含量的差异进行了研究。结果表明,(1)NaCl胁迫下,嫁接和自根植株生物量积累均受到显著抑制,嫁接植株受抑制较轻。(2)NaCl胁迫后,黄瓜嫁接、自根植株各器官Na 、Cl-含量均显著高于对照;嫁接植株除根系Na 含量显著高于自根植株外,其余各器官均显著低于自根植株;嫁接植株老叶、叶柄和根系的Cl-含量显著低于自根植株。(3)嫁接植株的根是主要的聚Na 部位,茎是主要的聚Cl-部位。(4)嫁接植株幼叶和根的K 、Ca2 、Mg2 含量均显著高于自根植株,嫁接植株的K /Na 、Ca2 /Na 、Mg2 /Na 值也均显著高于自根植株。以上结果证明,黄瓜嫁接植株根系和茎中盐离子的含量较高且对K 、Ca2 、Mg2 的选择性吸收、运输能力较强,在器官水平上盐分离子分布的区域化优于自根植株,从而使嫁接植株耐盐性强于自根植株。     

两个不同抗性黄瓜品种和云南黑籽南瓜根系分泌物对黄瓜枯萎病发生的影响

研究了黄瓜品种津研4号（感枯萎病）、津春4号（抗枯萎病）和云南黑籽南瓜根系分泌物对津研4号黄瓜枯萎病发生的影响及其原因.结果表明:感病品种根系分泌物处理的黄瓜枯萎病发病早,接种后第15天病株率显著高于对照,至第20天时病株率与对照相近;而抗病品种根系分泌物处理的病株率一直显著小于对照.感病品种根系分泌物浇灌的植株株高、鲜质量降低,根系活力下降、电导度（伤害度）增加,而抗病品种和云南黑籽南瓜根系分泌物处理对植株影响较小.感病品种根系分泌物促进了黄瓜枯萎病菌的生长,而抗病品种和云南黑籽南瓜根系分泌物则抑制了病菌生长.     

嫁接对铜胁迫下黄瓜根际土壤微生物特性和酶活性的影响

采用盆栽试验方法,研究了嫁接（以黑籽南瓜为砧木）对铜胁迫下黄瓜根际土壤微生物生物量、微生物种群数量和土壤酶活性的影响.结果表明： 铜胁迫下黄瓜根际土壤微生物生物量碳（MBC）和微生物生物量氮（MBN）含量显著下降,基础呼吸和代谢熵显著上升,但嫁接黄瓜根际土壤MBC和MBN含量显著高于自根黄瓜,而基础呼吸和代谢熵则显著低于自根黄瓜.铜胁迫下,根际土壤放线菌和自生固氮菌的数量显著下降,真菌数量显著上升,而细菌数量变化不显著;嫁接黄瓜根系土壤细菌、放线菌、自生固氮菌的数量显著高于自根黄瓜,而真菌数量显著低于自根黄瓜.嫁接黄瓜根际土壤脲酶、磷酸酶、蔗糖酶、过氧化氢酶活性在铜胁迫下显著高于自根黄瓜.试验结果证明嫁接使铜胁迫下黄瓜根际土壤微生物环境和酶活性得到了改善和提高,从而提高了黄瓜植株对铜胁迫的抵抗力.     

Crystal structure, detonation performance, and thermal stability of a new polynitro cage compound: 2, 4, 6, 8, 10, 12, 13, 14, 15-nonanitro-2, 4, 6, 8, 10, 12, 13, 14, 15-nonaazaheptacyclo [5.5.1.13, 11. 15, 9] pentadecane

A new polynitro cage compound 2, 4, 6, 8, 10, 12, 13, 14, 15-nonanitro-2, 4, 6, 8, 10, 12, 13, 14, 15-nonaazaheptcyclo [5.5.1.1(3,11).1(5,9)] pentadecane (NNNAHP) was designed in the present work. Its molecular structure was optimized at the B3LYP/6-31 G(d,p) level of density functional theory (DFT) and crystal structure was predicted using the Compass and Dreiding force fields and refined by DFT GGA-RPBE method. The obtained crystal structure of NNNAHP belongs to the P-1 space group and the lattice parameters are a = 9.99 ?, b = 10.78 ?, c = 9.99 ?, α = 90.01°, β = 120.01°, γ = 90.00°, and Z = 2, respectively. Based on the optimized crystal structure, the band gap, density of state, thermodynamic properties, infrared spectrum, strain energy, detonation characteristics, and thermal stability were predicted. Calculation results show that NNNAHP has detonation properties close to those of CL-20 and is a high energy density compound with moderate stability.     

Relations of the Al,B, Ba,Br, Ca,Cl, Cu,Fe, K,Li, Mg,Mn, Na,P, S,Si, Sr,and Zn mass fractions to morphometric parameters in pediatric and nonhyperplastic young adult prostate glands

The variation with age of the 18 trace element mass fractions and some histological characteristics of intact prostate glands of 50 subjects aged 0–30 years was investigated by instrumental neutron activation analysis, inductively coupled plasma atomic emission spectrometry, and a quantitative morphometric analysis. Mean values ± standard error of the mean (M ± SΕΜ) for the mass fractions (in milligrams per kilogram wet tissue) of these trace elements in pre-puberty were: Al 28.5 ± 9.0, B 0.40 ± 0.11, Ba 1.48 ± 0.44, Br 10.5 ± 1.5, Ca 241 ± 30, Cl 3,203 ± 278, Cu 3.51 ± 0.89, Fe 33.7 ± 4.1, K 2,364 ± 145, Li 0.020 ± 0.004, Mg 153 ± 23, Mn 0.46 ± 0.06, Na 2,286 ± 130, P 1,391 ± 100, S 1,698 ± 132, Si 62 ± 11, Sr 0.38 ± 0.08, and Zn 27.6 ± 2.3. During puberty and postpuberty, when there is a significant increase in circulating androgens, the mean values were: Al 7.2 ± 1.4, B 0.21 ± 0.05, Ba 0.25 ± 0.06, Br 5.8 ± 1.0, Ca 433 ± 81, Cl 2,314 ± 201, Cu 1.77 ± 0.13, Fe 20.9 ± 1.6, K 2,585 ± 118, Li 0.0088 ± 0.0014, Mg 232 ± 27, Mn 0.34 ± 0.04, Na 1,875 ± 107, P 1,403 ± 98, S 1,673 ± 73, Si 22.2 ± 3.1, Sr 0.22 ± 0.03, and Zn 93.3 ± 8.9. Mean values (M ± SΕΜ) of percent volumes (%) of the stroma, epithelium and lumen in the prostate before puberty were 73.4 ± 2.6, 20.4 ± 1.7, and 4.45 ± 0.94, respectively, versus 46.5 ± 2.5, 38.5 ± 1.9, and 14.9 ± 1.2 during puberty and postpuberty. This work’s results confirm that the Zn mass fraction in prostate tissue is an androgen-dependent parameter. For the first time it has been demonstrated that the glandular lumen is a main pool of Ca, Mg, and Zn accumulation and that the stroma is a main pool of Al, B, Ba, Br, Cl, Cu, Fe, Mn, Na, and Si accumulation in the normal human prostate, for the age range 0–30 years. It was concluded that the Ca, Mg, and Zn binds tightly within the prostatic fluid, because the volume of glandular lumen reflects the volume of prostatic fluid.     

Simultaneous measurement of the trace elements Al, As, B, Be, Cd, Co, Cu, Fe, Li, Mn, Mo, Ni, Rb, Se, Sr, and Zn in human serum and their reference ranges by ICP-MS

The goal of this article was to establish reference ranges of the concentration of trace elements in human serum and to compare these results with those reported by other authors. We describe the sample preparation and measurement conditions that allow the rapid, precise, and accurate determination of Al, As, B, Be, Cd, Co, Cu, Fe, Li, Mn, Mo, Ni, Rb, Se, Sr, and Zn in human serum samples (n=110) by inductively coupled plasma-mass spectrometry (ICP-MS). Accuracy and precision were determined by analyzing three reconstituted reference serum samples by comparison with other methods and by the standard addition procedure. The advantages of the ICP-MS method include short time of analysis of the elements mentioned, low detection limit, high precision, and high accuracy. Disadventages include a high risk of contamination due to the presence of some of the elements of interest in the environment, the relatively delicate sample handling, and the high cost of the equipment.     

The Effect of Age and Gender on Al, B, Ba, Ca, Cu, Fe, K, Li, Mg, Mn, Na, P, S, Sr, V, and Zn Contents in Rib Bone of Healthy Humans

The effect of age and gender on major, minor, and trace element contents in the intact rib bone of 80 relatively healthy 15–55-year-old women and men was investigated. Contents or upper limit of contents of 16 chemical elements in the rib bone were determined by inductively coupled plasma atomic emission spectrometry (ICP-AES). Mean values (M?±?SΕΜ) for the mass fraction of Ba, Ca, Cu, Fe, K, Li, Mg, Na, P, S, Sr, and Zn (milligram per kilogram of dry bone) were as follows: 2.54?±?0.16, 171,400?±?4,050, 1.35?±?0.22, 140?±?11, 1,874?±?71, 0.049?±?0.011, 2,139?±?38, 5,378?±?88, 75,140?±?1,660, 1,881?±?51, 291?±?20, and 92.8?±?1.5, respectively. The upper limits of contents of Al, B, Mn, and V were <7.20, <0.65, <0.36, and <0.03, respectively. Statistically significant tendency for the Ca, Mg, and P content to decrease with age was found in the human rib bone, regardless of gender. The mass fraction of Fe in the male rib bone increases with age. It was shown that higher Ca, Mg, Na, P, and Sr mass fractions as well as lower Fe content were typical of female ribs as compared to those in male ribs.     

Distribution of N,P, K,Ca, Mg,S, Zn,Fe, Mn and Cu in groundnut

Summary Concentration of N, P, K, Ca, Mg and S in summer groundnut crop was higher than in kharif while Zn, Fe, Mn and Cu contents were higher in summer crop. Kernel's N, P and Zn; Leaflet's Ca and Mn; Stem's K and Fe; Root's S and Cu and Petiole's Mg contents were highest. Shell's N, P, K, Mg, S, Zn and Cu; Kernel's Ca, Fe and Mn contents were the least. N, P, K, S, Zn and Cu concentrations decreased linearly as the crop grew. Ca, Mg, Fe and Mn concentrations did not display any distinct pattern. Ca concentration was positively correlated with pod yield in both the seasons.     

Reference values for the concentrations of As,Cd, Co,Cr, Cu,Fe, I,Hg, Mn,Mo, Ni,Pb, Se,and Zn in selected human tissues and body fluids

This report attempts to formulate reference ranges of elemental concentrations for 15 trace elements in selected human tissues and body fluids. A set of samples consisting of whole blood, blood serum, urine, milk, liver, and hair were chosen and considered for 15 elements of biological significance: As, Cd, Co, Cr, Cu, F, Fe, I, Hg, Mn, Mo, Ni, Pb, Se, and Zn. The results represent wholly or partially data received from 40 countries of the global regions of Africa, Asia, Europe, North, South, and Central America, Australia, and New Zealand. This survey, even if qualitative, has been useful in demonstrating certain trends of trace-element scenarios around the world. It is of course recognized that both diet and environment exert a strong influence on the distribution pattern of several elements, such as As, Cd, Mn, Pb, Se, and Zn. A limited comparison of the available information on soil status of different countries reflected some interesting associations for elements, such as Mn and Zn. Importantly, this study revealed that only a few countries were in a position to identify a reasonable amount of data on samples requested for this project. Regretably, for a number of countries, any dependable data for even such essential elements as Cu, Fe, and Zn were not available. In view of the nutritional importance of many elements, the time is ripe for concerted efforts by intergovernmental agencies to initiate investigations or commission task forces/projects to generate reliable reference data for selected global regions, which sadly lack data of any kind at present.     

New Coleoptera records from New Brunswick, Canada: Stenotrachelidae, Oedemeridae, Meloidae, Myceteridae, Boridae, Pythidae, Pyrochroidae, Anthicidae, and Aderidae

We report 19 new species records for the faunal list of Coleoptera in New Brunswick, Canada, six of which are new records for the Maritime provinces, and one of which is new Canadian record. We also provide the first recent records for five additional species in New Brunswick. One new species of Stenotrachelidae, Cephaloon ungulare LeConte, is added to the New Brunswick faunal list. Additional records are provided for Cephaloon lepturides Newman, as well the first recent record of Nematoplus collaris LeConte. Two species of Oedemeridae, Asclera puncticollis (Say) and Asclera ruficollis (Say), are newly reported for New Brunswick, and additional locality and bionomic data are provided for Calopus angustus LeConte and Ditylus caeruleus (Randall). The records of Ditylus caerulus are the first recent records for the province. Three species of Meloidae, Epicauta pestifera Werner, Lytta sayi LeConte, and Meloe augustcollis Say are reported the first time for New Brunswick; Epicauta pestifera is newly recorded in Canada. Lacconotus punctatus LeConte and the family Mycteridaeis newly recorded for New Brunswick. The first recent records of Borus unicolor Say (Boridae) are reported from the province. One new species of Pythidae, Pytho siedlitzi Blair, and the first recent records of Pytho niger Kirby are added to the faunal list of New Brunswick. Three species of Pyrochroidae are newly reported for the province, including Pedilus canaliculatus (LeConte) and Pedilus elegans (Hentz), which are new for the Maritime provinces. Five species of Anthicidae and the first recent record of Anthicus cervinus LaFerté-Sénectére are newly reported for New Brunswick. Anthicus melancholicus LaFerté-Sénectère, Sapintus pubescens (LaFerté-Sénectère), Notoxus bifasciatus (LeConte), and Stereopalpus rufipes Casey are new to the Maritime provinces faunal list. Ambyderus granularis (LeConte) is removed from the faunal list of the province. Three species of Aderidae, Vanonus huronicus Casey, Zonantes fasciatus (Melsheimer), and Zonantes pallidusWerner, are newly recorded for New Brunswick; Zonantes fasciatus and Vanonus huronicus are new for the Maritime provinces' faunal list. Collection data, bionomic data, and distribution maps are presented for all these species.     

Potential Compounds for Oral Cancer Treatment: Resveratrol,Nimbolide, Lovastatin,Bortezomib, Vorinostat,Berberine, Pterostilbene,Deguelin, Andrographolide,and Colchicine

Oral cancer is one of the main causes of cancer-related deaths in South-Asian countries. There are very limited treatment options available for oral cancer. Research endeavors focused on discovery and development of novel therapies for oral cancer, is necessary to control the ever rising oral cancer related mortalities. We mined the large pool of compounds from the publicly available compound databases, to identify potential therapeutic compounds for oral cancer. Over 84 million compounds were screened for the possible anti-cancer activity by custom build SVM classifier. The molecular targets of the predicted anti-cancer compounds were mined from reliable sources like experimental bioassays studies associated with the compound, and from protein-compound interaction databases. Therapeutic compounds from DrugBank, and a list of natural anti-cancer compounds derived from literature mining of published studies, were used for building partial least squares regression model. The regression model thus built, was used for the estimation of oral cancer specific weights based on the molecular targets. These weights were used to compute scores for screening the predicted anti-cancer compounds for their potential to treat oral cancer. The list of potential compounds was annotated with corresponding physicochemical properties, cancer specific bioactivity evidences, and literature evidences. In all, 288 compounds with the potential to treat oral cancer were identified in the current study. The majority of the compounds in this list are natural products, which are well-tolerated and have minimal side-effects compared to the synthetic counterparts. Some of the potential therapeutic compounds identified in the current study are resveratrol, nimbolide, lovastatin, bortezomib, vorinostat, berberine, pterostilbene, deguelin, andrographolide, and colchicine.