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Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth 总被引:5,自引:0,他引:5 下载免费PDF全文
Fu M Rao M Wang C Sakamaki T Wang J Di Vizio D Zhang X Albanese C Balk S Chang C Fan S Rosen E Palvimo JJ Jänne OA Muratoglu S Avantaggiati ML Pestell RG 《Molecular and cellular biology》2003,23(23):8563-8575
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Interaction and functional cooperation between the LIM protein FHL2, CBP/p300, and beta-catenin 总被引:1,自引:0,他引:1 下载免费PDF全文
Labalette C Renard CA Neuveut C Buendia MA Wei Y 《Molecular and cellular biology》2004,24(24):10689-10702
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Hirota M Watanabe K Hamada S Sun Y Strizzi L Mancino M Nagaoka T Gonzales M Seno M Bianco C Salomon DS 《Cellular signalling》2008,20(9):1632-1641
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p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation 总被引:10,自引:0,他引:10
Fu M Wang C Reutens AT Wang J Angeletti RH Siconolfi-Baez L Ogryzko V Avantaggiati ML Pestell RG 《The Journal of biological chemistry》2000,275(27):20853-20860
The androgen receptor (AR) is a sequence-specific DNA-binding protein that plays a key role in prostate cancer cellular proliferation by dihydrotestosterone and the induction of secondary sexual characteristics. In this study we demonstrate that the AR can be modified by acetylation in vitro and in vivo. p300 and p300/cAMP-response element-binding protein acetylated the AR at a highly conserved lysine-rich motif carboxyl-terminal to the zinc finger DNA-binding domain. [(14)C]acetate-labeling experiments demonstrated that AR acetylation by p300 in cultured cells requires the same residues identified in vitro. Point mutation of the AR acetylation site (K632A/K633A) abrogated dihydrotestosterone-dependent transactivation of the AR in cultured cells. Mutation of the p300 CH3 region or the p300/cAMP-response element-binding protein histone acetylase domain reduced ligand-dependent AR function. The identification of the AR as a direct target of histone acetyltransferase co-activators has important implications for targeting inhibitors of AR function. 相似文献
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Ianculescu I Wu DY Siegmund KD Stallcup MR 《The Journal of biological chemistry》2012,287(6):4000-4013