共查询到20条相似文献,搜索用时 500 毫秒
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New insights into TGF-beta-Smad signalling 总被引:1,自引:0,他引:1
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How the Smads regulate transcription 总被引:4,自引:0,他引:4
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TGF-beta signalling through the Smad pathway 总被引:2,自引:0,他引:2
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Signaling inputs converge on nuclear effectors in TGF-beta signaling 总被引:17,自引:0,他引:17
Recent studies have consolidated the pivotal role of Smads as intracellular effectors of TGF-beta family members. Upon binding to their specific type I and type II serine/threonine kinase receptors, each family member activates a particular subset of Smad proteins. Activated, receptor-regulated Smads form hetero-oligomeric complexes with common-partner Smads that translocate into the nucleus, where they control the expression of target genes in a cell-type-specific manner. Smads appear to function not only as nuclear effectors for TGF-beta family members, but as signal integrators within an extensive intracellular network. 相似文献
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Regulation of cell proliferation by Smad proteins 总被引:40,自引:0,他引:40
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Filamin associates with Smads and regulates transforming growth factor-beta signaling 总被引:9,自引:0,他引:9
Sasaki A Masuda Y Ohta Y Ikeda K Watanabe K 《The Journal of biological chemistry》2001,276(21):17871-17877
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TGF-beta and the Smad signal transduction pathway. 总被引:31,自引:0,他引:31
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TGF-beta signaling from receptors to the nucleus 总被引:13,自引:0,他引:13
Roberts AB 《Microbes and infection / Institut Pasteur》1999,1(15):1265-1273
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E1A inhibits transforming growth factor-beta signaling through binding to Smad proteins. 总被引:2,自引:0,他引:2
A Nishihara J Hanai T Imamura K Miyazono M Kawabata 《The Journal of biological chemistry》1999,274(40):28716-28723
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TGF-beta signaling by Smad proteins 总被引:26,自引:0,他引:26
Miyazono K 《Cytokine & growth factor reviews》2000,11(1-2):15-22
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