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A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation 总被引:7,自引:0,他引:7 下载免费PDF全文
Nuclear receptor corepressors SMRT (silencing mediator of retinoid and thyroid receptors) and N-CoR (nuclear receptor corepressor) recruit histone deacetylase (HDAC) activity to targeted regions of chromatin. These corepressors contain a closely spaced pair of SANT motifs whose sequence and organization is highly conserved. The N-terminal SANT is a critical component of a deacetylase activation domain (DAD) that binds and activates HDAC3. Here, we show that the second SANT motif functions as part of a histone interaction domain (HID). The HID enhances repression by increasing the affinity of the DAD-HDAC3 enzyme for histone substrate. The two SANT motifs synergistically promote histone deacetylation and repression through unique functions. The HID contribution to repression is magnified by its ability to inhibit histone acetyltransferase enzyme activity. Remarkably, the SANT-containing HID preferentially binds to unacetylated histone tails. This implies that the SMRT HID participates in interpreting the histone code in a feed-forward mechanism that promotes and maintains histone deacetylation at genomic sites of SMRT recruitment. 相似文献
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A feed-forward repression mechanism anchors the Sin3/histone deacetylase and N-CoR/SMRT corepressors on chromatin 总被引:3,自引:0,他引:3 下载免费PDF全文
Vermeulen M Walter W Le Guezennec X Kim J Edayathumangalam RS Lasonder E Luger K Roeder RG Logie C Berger SL Stunnenberg HG 《Molecular and cellular biology》2006,26(14):5226-5236
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Function of the ING family of PHD proteins in cancer 总被引:11,自引:0,他引:11
Gong W Suzuki K Russell M Riabowol K 《The international journal of biochemistry & cell biology》2005,37(5):1054-1065
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Grégoire S Xiao L Nie J Zhang X Xu M Li J Wong J Seto E Yang XJ 《Molecular and cellular biology》2007,27(4):1280-1295
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Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation 总被引:20,自引:0,他引:20 下载免费PDF全文
Koumenis C Alarcon R Hammond E Sutphin P Hoffman W Murphy M Derr J Taya Y Lowe SW Kastan M Giaccia A 《Molecular and cellular biology》2001,21(4):1297-1310
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