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1.
Superoxide dismutase activity and zinc and copper concentrations in growth retardation 总被引:1,自引:0,他引:1
The aim of this study was to determine the effects of oral zinc treatment on red cell copper/zinc-superoxide dismutase (Cu/Zn-SOD)
activity and zinc and copper concentrations in growth retardation.
Thirty-five patients, average age of 11 yr, were selected. The control group consisted of 10 healthy children whose average
age was 10 yr. Superoxide dismutase activity was determined by spectrophotometer. Copper and zinc concentrations were measured
by an atomic absorption spectrophotometer. The activity of Cu/Zn-SOD before zinc treatment was higher than the controls (p<0.001). There was a decrease in Cu/Zn-SOD activity after zinc treatment (p<0.001) and the values after treatment were still higher than the controls (p<0.001). Plasma zinc concentrations before zinc treatment were lower than controls (p<0.01). After treatment, there was an increase in plasma zinc concentrations compared to controls and the patients' values
before zinc treatment, respectively (p<0.001, p<0.001). After zinc treatment, plasma copper concentrations were decreased significantly (p<0.01). An increase in red cell zinc concentration (p<0.01) and a decrease in copper concentration (p<0.001), which were statistically significant, were seen after zinc treatment.
The results suggested that there were significant alterations in Cu/Zn-SOD activity and zinc and copper concentrations during
growth retardation. With zinc treatment, these parameters appeared to approach normal values. 相似文献
2.
Pelin Aribal Kocatürk M. Cenk Akbostanci Canan Işikay Aylin Öcal Deniz Tuncel Güzin Özelçi Kavas Nermin Mutluer 《Biological trace element research》2001,80(2):115-124
Ischemia is associated with the pathological changes caused by the accumulation of reactive oxygen metabolites (ROM) in cerebrovascular
accident (CVA). The aim of this study was to determine red cell copper/zinc-superoxide dismutase (Cu/Zn-SOD) and catalase
activities and copper and zinc concentrations both in plasma and in red cells in CVA. Cu/Zn-SOD and catalase activities of
16 patients, with an average age of 64 yr, were measured spectrophotometrically; copper and zinc concentrations were determined
by atomic absorption spectrophotometer. The results showed that Cu/Zn-SOD activity was increased markedly in patients compared
to the young controls and reached a peak on the d 5 of the disease, whereas the catalase activity of the patients on d 3 and
d 5 were in the normal range, but higher on d 10. The enzyme activities of the elderly group were generally increased compared
to the young controls. Copper and zinc concentrations showed corresponding alterations. These findings suggested that the
effects of oxidative stress in CVA might be reflected in red cell and plasma parameters.
Presented at the III International Congress of Pathophysiology, Lahti, Finland, 28 June–3 July, 1998. 相似文献
3.
Olusi S Al-Awadhi A Abiaka C Abraham M George S 《Biological trace element research》2003,91(2):137-144
Leptin, the obesity gene protein product, is a hormone with multiple physiological functions in the human. However, there
are few reports in the literature on its role in trace element metabolism in the normal population. Therefore, we investigated
the association among serum leptin, zinc, copper, and zinc/copper ratio in 570 healthy men and women aged 15 yr and older.
Serum leptin assay was done with a commercial enzymelinked immunosorbent assay kit; serum zinc and copper levels were measured
by an atomic absorption spectrophotometer. Serum leptin was found to be positively associated with age (r=0.254, p<0.001), sex (r=0.406, p<0.001), body mass index (BMI) (r=0.553, p<0.001), and serum copper (r=0.419, p<0.001), but negatively associated with the zinc/copper ratio (r=−0.423, p<0.001). There was no significant association between serum leptin and zinc (r=−0.131, p>0.05). When the confounding effects of age, sex, and BMI were removed, serum leptin was still positively associated with
serum copper (r=0.197, p=0.02) and the serum zinc/copper ratio (r=−0.182, p=0.03). These results suggest that copper and not zinc has an effect on serum leptin levels. 相似文献
4.
Hypertension: does impaired endothelium-dependent relaxation affect superoxide scavenging? 总被引:3,自引:0,他引:3
The purpose of this study was to investigate the effects of acute nitric oxide synthase inhibition on mean arterial blood
pressure, oxidative stress markers such as plasma malondialdehyde (MDA) concentration, intracellular antioxidant enzyme activities
such as copper-zinc superoxide dismutase (Cu/Zn SOD) and catalase and on trace elements important for activity and stability
of Cu/Zn-SOD.
Wistar-Kyoto rats (approx 150 g) (n=11) were treated with N
ω-nitro-l-arginine methyl esther (l-NAME) (0.5 mg/mL) for 2 d. Age- and bodyweight-matched rats (n=10) were used for control group. Their systolic blood pressures and heart rates were recorded daily during the experimental
period and also before their blood samples were drawn. Plasma MDA, plasma and red cell zinc and copper concentrations, and
red cell Cu/Zn-SOD and catalase activities were determined.
A progressive rise in systolic arterial blood pressure was observed compared to the control group (p<0.001). The heart rate of the experimental group was reduced on the third day (p<0.05). Plasma MDA concentration and red cell catalase activity were increased in the experimental group (p<0.001 and p<0.001, respectively). Plasma copper and red cell zinc concentrations were also increased significantly in the experimental
group (p<0.001 and p<0.01, respectively).
In conclusion, impairment in endothelium-derived relaxation altered mean arterial blood pressure, oxidant status, and trace
element concentrations.
Presented at the Advanced Course (sponsored by NATO-ASI, SFRR, FEBS, UNESCO-MCBN, IUBMB) “Free Radicals, Nitric Oxide, and
Inflamation: Molecular, Biochemical, and Clinical Aspects,” Lara, Antalya, Turkey, September 23–October 3, 2001. 相似文献
5.
The plasma and erythrocyte levels of zinc, copper, and magnesium and the activities of red-cell copper-zinc superoxide dismutase
(Cu/Zn-SOD) and catalase (CAT) were determined in patients with benign and malignant tumors of the larynx. Blood samples from
patients and healthy controls were drawn using heparinized tubes. The erythrocyte Cu/Zn-SOD and CAT activities were determined
spectrophotometrically and the zinc, copper, and magnesium concentrations were determined in erythrocyte and plasma by atomic
absorption spectrometry. Variance analysis was employed in the statistical evaluation of the findings.
There was a significant increase in red-cell Cu/Zn-SOD activity in the subjects with malignant and benign tumors compared
to controls (p<0.001). The CAT activity increased only in the benign tumor group (p<0.01). The plasma zinc concentrations were significantly lower in the malignant tumor group (p<0.05) and significantly higher in the benign tumor group (p<0.01). The erythrocyte copper concentrations were significantly lower in both benign and malignant tumor groups (p<0.001). The plasma copper and magnesium and the erythrocyte magnesium concentrations did not show significant differences
relative to controls (p>0.05).
The increases in the activities of SOD and CAT activities and the changes in trace elements concentrations can indicate the
presence of increased reactive oxygen species that might play a part in the pathogenesis larynx tumors.
Presented at the IX Asian-Pacific Congress of Clinical Biochemistry, March 9–14, 2002, New Delhi, India. 相似文献
6.
Jaume Folch Arturo Ortega Maria Cabré José L. Paternáin 《Biological trace element research》1998,63(2):113-121
The monitoring of heavy metals is important if adverse effects on health are to be avoided. In humans, metallothionein (MT)
has been used as a biomonitor for the assessment of cadmium (Cd). In the present study, subjects drawn from the population
of Tarragona Province (NE Spain) were investigated. Urinary MT, zinc (Zn), and copper (Cu) concentrations, corrected for creatine
concentrations, were determined in 625 samples from healthy subjects aged between 10 and 65 yr. Mean values of MT and Cu in
females were higher than those in males, with levels of 29.5 (23.8) vs. 22.7 (24.9) μg MT/creatinine (p<0.001) and 4.8 (6.1) vs 3.4 (4.9) μg Cu/g creatinine (p<0.001). No differences between males and females were observed with respect to urinary Zn: 78.0 (66.4) vs 73.0 (85.5) μg/g
creatinine, respectively (p=0.332). Significantly higher MT, Zn, and Cu values were observed in the females aged 15–19 yr and, in the age group of 50–54
yr, only in the Zn and Cu values, when compared with those in males. Significant positive correlations of MT vs Zn and Cu
as well as correlations of Zn vs Cu levels were observed in both genders. The present findings confirm the proposed role of
MT as a biomonitor of mineral status. 相似文献
7.
Gürgöze MK Olçücü A Aygün AD Taskin E Kiliç M 《Biological trace element research》2006,111(1-3):23-29
In the present study, the serum and hair levels of zinc, selenium, and copper were determined in children with iron-deficiency
anemia (IDA). A total of 52 anemic children aged 1–4 yr constituted the study group. Fortysix healthy children acted as controls.
The copper and zinc levels were measured with an atomic absorption spectrophometer. Serum and hair selenium was determined
by a spectroflourometric method. The serum zinc and selenium concentrations in the IDA group were found to be significantly
lower and serum copper significantly higher than those in the controls (p<0.05). Lower iron, zinc, and selenium concentrations (p<0.001) but not copper were found in hair (p>0.05). 相似文献
8.
Aydin Ece Bekir Sami Uyamik Akin IŞcan Pelin Ertan M. Ramazan Yiğitolu 《Biological trace element research》1997,59(1-3):31-39
In order to evaluate serum copper and zinc status in children with iron deficiency anemia (IDA), 60 children with IDA aged
1–14 yr and 64 healthy children as controls aged 1–14 yr were included the study. Serum copper levels were higher in children
with IDA (189 ± 49 (Μg/dL) than those of controls (163 ± 37 Μg/dL) (p = 0.001). Serum zinc levels were lower in the patient group (109 ± 59 Μg/dL) than those of control subjects (135 ± 56 Μg/dL)
(p = 0.017). In addition, there were statistically significant negative correlations between hematological parameters and serum
copper levels in the patient group, but not in controls. No correlation between hematological parameters and serum zinc levels
were found in both patient and control groups, except positive correlation between mean corpuscular volume (MCV) and serum
zinc level in patients.
It was concluded that at the time of managing children with IDA, zinc deficiency must be borne in mind and if necessary treatment
should be initiated with zinc. 相似文献
9.
Lech T 《Biological trace element research》2002,89(2):111-125
The lead, copper, zinc, and magnesium contents of scalp hair taken from 173 children aged 1–15 yr and young people (16–18
yr) with certain disorders of the osteomuscular articular system (osteomuscular pains of unknown origin, once described as
“growing pains”) were measured, using the flame atomic absorption spectrometry method, and then compared with those of 108
normal, healthy children. The research showed increased average levels of lead (a statistically significant p<0.05 in both the overall group of children, and in those over 11 yr old), and zinc (increased in the total group, in a statistically
significant way at p<0.10 only in adolescents over 15 yr old) and decreased levels of copper (although not significantly) in the hair of children
suffering from “rheumatic” diseases, as compared with controls. The magnesium levels for the total group of ill children were
admittedly enhanced, but in the youngest children, the levels were reduced.
The values of the Mg/Pb and Mg/Zn ratios were lower (in the youngest children, 70% decrease of the Mg/Pb ratio) and Zn/Cu
were higher in the group of children suffering from rheumatic diseases than in the healthy children. The difference of Mg/Pb
ratio between the total controls and rheumatic subjects was statistically significant at p<0.05 and the Zn/Cu at p<0.10. The Mg/Zn ratio was not statistically significant. 相似文献
10.
Feridun Kosar Ibrahim Sahin Nusret Acikgöz Yuksek Aksoy Zehra Kucukbay Sengul Cehreli 《Biological trace element research》2005,107(1):1-9
It is known that certain trace elements can affect various heart diseases. In this study, we aimed to evaluate the changes
in concentrations of certain serum trace elements in patients with chronic rheumatic heart disease (RHD). Serum analysis of
selenium (Se), zinc (Zn), and copper (Cu) trace elements was assayed by atomic absorption spectrophotometry. RHD patients
had significantly lower serum concentrations of Se and Zn than control subjects (p<0.05 and p<0.001, respectively). However, the serum Cu concentration was significantly higher in RHD patients than in controls (1.93±0.59
μg/L vs 1.06±0.29 μg/L; p<0.001). Similarly, the Cu/Zn ratio in RHD patients was higher than in control subjects (4.70±0.92 vs 1.68±0.45; p<0.001). Additionally, no significant correlation was found among these trace element concentrations and the functional capacity
classes (p>0.05). RHD patients had decreased serum Se and Zn element concentrations and increased serum Cu element concentration. We
suggest that Se and Zn deficiency might be contributory factors in the development of rheumatic heart disease, and a high
Cu concentration and a high Cu/Zn ratio might reflect an ongoing inflammatory process in this disease. 相似文献
11.
The aim of the present study is to evaluate the status of plasma essential trace elements selenium (Se), zinc (Zn), copper
(Cu), and iron (Fe) concentrations and their related acute-phase proteins, ceruloplasmin (Cp), ferritin, transferrin (Tf),
and albumin levels in patients with vivax malaria. Plasma Cu and Zn concentrations were determined by atomic absorption spectrometry
(AAS). Se concentrations were determined by graphite furnace AAS. Fe, Cp, Tf, and albumin levels were determined by colorimetric
methods. Plasma Se, Fe, and albumin levels were found to be significantly lower (p<0.01, p<0.001, and p<0.05, respectively) and Cu, Cp, and ferritin levels and Cu/Zn ratios were significantly higher (p<0.001, p<0.001, p<0.001, and p<0.05, respectively) in patients when compared with those of healthy subjects. Plasma, Tf, and Zn levels were not found to
be significantly different (p>0.05) in patients and controls. There were positive important correlations between Cu and Cp (r=0.908, p<0.001), Zn and albumin (r=0.633, p<0.001), and negative correlations between Fe and ferritin content (r=−0.521, p<0.05) and Fe and Tf (r=−0.616, p<0.01) in the patients group. Our findings demonstrated that plasma essential trace elements Se, Cu, and Fe change, but these
changes might be dependent on acute-phase proteins, which were regulated as a part of defense strategies of the organism,
induced by hormonelike substances. 相似文献
12.
Ze-peng Y Guo-wei L Hong-yu H Yun-yu W Yong-hui S 《Biological trace element research》2005,105(1-3):215-227
This experiment was conducted to investigate the effects of zinc sulfate and zinc methionine (Zn-Met) and their levels on
apoptosis induced by glucocorticoid of thymocytes and the possible mechanism. Dexamethasone was used to make the apoptosis
model of thymocytes; zinc sulfate and zinc methionine were supplemented to the medium at levels of 0,50, 100, 500, and 1000
μM. The activity of cells,Cu,Zn superoxide dismutase (Cu,Zn-SOD), DNA ladder pattern, intracellular calcium concentration, and
the percentage of apoptosis nuclei were determined.
Both ZnSO4 and Zn-Met could modulate apoptosis; they inhibited apoptosis and decreased DNA fragmentation. The regulation was concentration
dependent. At levels of 50 and 100 μM, the effect of Zn-Met on inhibiting apoptosis was less efficient than that of ZnSO4 (p<0.05), but the activity of the cells cultured with Zn-Met was higher than those cultured with ZnSO4; they showed no difference in modulating apoptosis when added at levels of 500 and 1000 μM to the medium (p>0.05). Intracellular calcium concentrations of cells cultured with Zn-Met were higher than those cultured with ZnSO4 at the same levels. Zinc supplementation decreased the concentration of intracellular calcium significantly (p<0.05) and increased the activity of Cu,Zn-SOD in the extract of the cells (p<0.05). Both zinc sulfate and Zn-Met could modulate apoptosis of thymocytes induced by glucocorticoid; the mechanism might
involve the exchange of intracellular calcium, the redox of cells, and the two forms of zinc might go different ways in the
regulations. 相似文献
13.
Canatan H Bakan I Akbulut M Halifeoglu I Cikim G Baydas G Kilic N 《Biological trace element research》2004,100(2):117-123
Obesity is among the main contributing factors in the etiology of essential hypertension (EHT). Leptin, the product of the
ob gene, is expressed mainly in adipose tissue. We examined the relationship between two trace elements, zinc (Zn) and copper
(Cu), and leptin in patients with EHT (n=35) and normotensive (NT) controls (n=50) because leptin as well as Zn and Cu were reported to be associated with the pathophysiology of EHT. Plasma leptin levels
were determined with a commercial enzyme-linked immunosorbent assay (ELISA) kit. Atomic absorption spectrophotometry was utilized
to determine plasma Zn and Cu levels. There was a negative correlation between leptin and Zn, and the Zn/Cu ratio (r=−0.359, p<0.05; r=0.361, p<0.05, respectively) in pooled subjects. When subjects were divided based on the presence or absence of hypertension, there
was a negative correlation between leptin and Zn (r=−0.375, p<0.05) as well as leptin and Zn/Cu ratio (r=−0.398, p<0.05) in NT subjects. Similar trends were observed when leptin/BMI (body mass index) levels were utilized. There was no significant
correlations between levels of Cu and leptin or leptin/BMI. In conclusion, in addition to high leptin levels, Zn and the Zn/Cu
ratio were lower in patients with EHT compared to NT controls. 相似文献
14.
Women with preeclampsia have been shown to have elevated blood levels of the metabolite homocysteine, and alterations in blood
levels of zinc and copper have also been reported. This study measured plasma levels of zinc, copper, and homocysteine in
women with preeclampsia and in women with healthy, normotensive pregnancies.
For the patients with preeclampsia compared with controls, significantly higher mean plasma levels were found of homocysteine
(16.39 vs 9.45 nmol/mL; p≤0.001), zinc (15.53 vs 11.93 μg/g protein; p < 0.05), and copper (47.90 vs 31.60 μg/g protein; p=0.001). The ratio of plasma Cu/Zn levels tended to be higher in preeclamptic women and could be taken as an index of inflammatory
reaction, but the difference was not significant. Homocysteine concentrations correlated positively with plasma zinc concentrations
in women with preeclampsia (r=0.588, p=0.003) but not in women with healthy pregnancies. No correlations were observed between plasma levels of homocysteine and
copper.
Thus, the present study found evidence that preeclampsia might be associated with hyperhomocysteinemia and elevated blood
levels of zinc and copper. Furthermore, elevated blood levels of zinc were significantly associated with hyperhomocysteinemia
in preeclampsia. More studies are warranted to investigate further any relationship between altered homocysteine metabolism
and levels of zinc and copper in preeclampsia. 相似文献
15.
Lead, copper, zinc, and magnesium content in hair of children and young people with some neurological diseases 总被引:1,自引:0,他引:1
Lech T 《Biological trace element research》2002,85(2):111-126
The lead, copper, zinc, and magnesium levels of scalp hair taken from 153 children aged 1–15 yr and young people (16–18 yr)
with selected neurological disorders (hyperexcibility, loss of consciousness, and epileptiform convulsions of an unknown origin,
etc.), were measured using the atomic absorption spectrometry method and then compared with a control group of healthy children
(n=108). The research indicated significantly reduced mean levels of magnesium in the hair of children suffering from selected
neurological diseases (in children aged 11–15 yr of age, above 30%; up to 5 yr of age, nearly 30%; the differences were statistically
significant at p<0.05) and slightly decreased mean levels of copper (differences statistically significant at p<0.05, particularly in the 11 to 15-yr category). Differences in zinc levels in hair were inconsiderable (not statistically
significant in any age groups). The lead level in the hair of the above-mentioned group of children was exceeded in relation
to the control group (a statistically significant difference at p<0.05 for the total group). A more than twofold decrease in the mean value of the Mg/Pb ratio (and a nearly 30% decrease in
the value of the Mg/Zn ratio) in the hair of children suffering from neurological diseases suggests that the high toxicity
of lead accompanying, among other things, magnesium deficiencies might be a cause of the observed disorders in children. 相似文献
16.
The aim of the present study is to evaluate the status of plasma essential trace element selenium (Se), manganese (Mn), copper
(Cu), zinc (Zn), and iron (Fe) concentrations and the effect of these elements on oxidative status in patients with childhood
asthma. Plasma Se, Mn, Cu, and Zn concentrations were determined by atomic absorption spectrophotometry (AAS) and Fe concentrations,
malondialdehyde (MDA), and total antioxidant capacity (TAC) were determined by the colorimetric method. The plasma MDA/TAC
ratio was calculated as an index of oxidative status. Plasma albumin levels were measured to determine nutritional status.
Plasma Fe concentrations, MDA levels and the MDA/TAC ratio were significantly higher (p<0.001, p<0.001, and p<0.01, respectively) and Se and Mn concentrations and TAC were lower (p<0.01, p<0.05, and p<0.01, respectively) in patients when compared to the healthy subjects. Plasma Zn, Cu, and albumin levels were not found to
be significantly different in patients and controls (p>0.05). There were positive relationships between plasma MDA and Fe (r=0.545, p<0.001) and TAC and Se (r=0.485, p<0.021), and a negative correlation between TAC and MDA values (r= −0.337, p<0.031) in patients with childhood asthma. However, there was no correlation between these trace elements and albumin content
in patient groups. These observations suggest that increased Fe and decreased Se concentrations in patients with childhood
asthma may be responsible for the oxidant/antioxidant imbalance. 相似文献
17.
Essential elements, mainly selenium and zinc, were involved in protection against oxidative stress in cells. Oxidation could
lead to the formation of free radicals that have been implicated in the pathogenesis of many diseases, including leukemia.
Leukemia is a neoplastic disease that is susceptible to antioxidant enzyme and essential elements alterations. This study
was undertaken to examine the levels of essential elements, antioxidant enzymes activities, and their relationships with different
types of leukemia. Serum selenium, zinc, and copper concentrations, red blood cell glutathione peroxidase (GPx) activities,
plasma Cu−Zn superoxide dismutase (Cu−Zn SOD) activities and lipid peroxidation (LPO) levels were determined in 49 patients
with different types of leukemia before initial treatment. Serum selenium and zinc concentrations were lower in leukemia patients
than those of controls (p<0.01). Serum copper concentration was higher in leukemia patients than that of controls (p<0.01). The activities GPx and Cu−Zn SOD were significantly increased in leukemia patients, especially with acute leukemia
(AL), acute lymphoid leukemia (ALL), and acute nonlymphoid leukemia (ANLL) (p<0.05), whereas no difference was found between those of chronic myelogeneous leukemia and the controls. The levels of LPO
were normal as controls. Serum selenium concentration was not correlated with GPx, and serum levels of zinc and copper were
not related to Cu−Zn SOD. Serum zinc levels had a negative correlation with the absolute peripheral blast cells, whereas serum
copper had a positive correlation with the absolute peripheral blast cells. Increased GPx and Cu−Zn SOD activities and normal
levels of LPO, which were a protective responses, were an indicator of mild oxidative stress; it mights indicate that the
essentials elements alterations in leukemia patients were mostly dependent on tumor activity. Changes of their levels demonstrated
that there are low selenium, zinc, and high copper status in leukemia patients. The decrease of plasma zinc and increase of
the Cu/Zn ratio could be the index that showed an unfavorable prognosis of acute leukemia. 相似文献
18.
Abdellatif Chakar Ridha Mokni Philip A. Walravens Philippe Chappuis Fanny Bleiberg-Daniel Jean-Louis Mahu Daniel Lemonnier 《Biological trace element research》1993,38(1):97-106
Plasma zinc, copper, and parameters of growth were measured in a group of 116 French preschool children, 2–5 yr-old from low-income
households. Participants were selected on the basis of Z-scores of weight for height (WHZ) and height for age (HAZ). Zinc
and copper concentrations of children with growth impairment (GI), defined by a WHZ and/or HAZ< −1 Z-score, were compared
to those of age, sex, and ethnic origin matched controls (WHZ and HAZ >−1 Z-score). Mean (±SD) plasma zinc concentration was
12.58±1.84 μmol/L in the GI group, and 13.27±1.98 μmol/L in the controls. The difference of the means of paired samples was
0.69±2.34, and by pairedt-test the significance reachedp=0.028. This effect was primarily a result of the weight retarded group (WHZ <−1 Z-score,p<0.009) and to the girls (p<0.05). There were no significant differences in plasma copper concentrations between groups. These results suggest the presence
of marginal zinc deficiency in French preschool children with low weight for height Z-scores. 相似文献
19.
In this study, we investigated the impact of ischemia-reperfusion on antioxidant enzyme activities and trace element concentrations.
For this purpose, ischemia was initiated by clamping superior mesenteric artery of Wistar (albino) rats for 30 min, followed
by reperfusion for 20 min. Immediately after reperfusion, blood samples were taken and examined for red cell copper-zinc superoxide
dismutase (Cu-Zn-SOD), catalase (CAT), and glutathione peroxidase (GPx) activities spectrophotometrically and plasma zinc,
copper, and magnesium concentrations by atomic absorption spectrophotometer. In the ischemiareperfusion group, red cell Cu-Zn-SOD
activity and plasma zinc and copper concentrations were increased significantly (p<0.001) when compared to the control group; however, the increases in GPx activity and plasma magnesium concentration were
not significant (p>0.05). We also found a significant (p<0.01) decrease in catalase activity. Free radicals released as a consequence of ischemia-reperfusion caused significant alterations
in antioxidant enzymes and in the concentrations of trace elements.
Presented at III International Congress of Pathophysiology 1998, Lahti, Finland. 相似文献
20.
Koury JC de Oliveira Kde J Lopes GC de Oliveira AV Portella ES de Moura EG Donangelo CM 《Biological trace element research》2007,115(1):23-30
This study evaluated levels of plasma zinc, copper, and leptin, body composition, and their relationship in nine elite female
judo athletes under two different training conditions. Body composition and biochemical measurements (hematological indexes,
plasma zinc, plasma copper, and plasma leptin) were analyzed 24 h after intense training and following a 5-d period without
training (no-training). Plasma leptin and plasma zinc increased with no-training. Plasma zinc correlated negatively with percent
fat mass (r=−0.62; r=0.05) and positively with plasma leptin (r=0.83; p=0.002) in the no-training condition Plasma copper did not change during the study and correlated positively with plasma leptin
(r=0.66; p=0.05) and with percent fat mass (r=0.80; p=0.007) after training. Percent fat mass was associated negatively with plasma zinc (r=−0.62; p=0.05) in the no-training condition. Moreover percent fat mass was negatively associated with the Zn/Cu plasma ratio under
both training conditions (r<−0.78, p<0.001). These results are consistent with the possible function of zinc as a lipid-mobilizing factor and of copper
as a limiting factor in energy metabolism. 相似文献