共查询到20条相似文献,搜索用时 15 毫秒
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Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila 总被引:1,自引:0,他引:1
Bell O Wirbelauer C Hild M Scharf AN Schwaiger M MacAlpine DM Zilbermann F van Leeuwen F Bell SP Imhof A Garza D Peters AH Schübeler D 《The EMBO journal》2007,26(24):4974-4984
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Alekseyenko AA Peng S Larschan E Gorchakov AA Lee OK Kharchenko P McGrath SD Wang CI Mardis ER Park PJ Kuroda MI 《Cell》2008,134(4):599-609
The Drosophila MSL complex associates with active genes specifically on the male X chromosome to acetylate histone H4 at lysine 16 and increase expression approximately 2-fold. To date, no DNA sequence has been discovered to explain the specificity of MSL binding. We hypothesized that sequence-specific targeting occurs at "chromatin entry sites," but the majority of sites are sequence independent. Here we characterize 150 potential entry sites by ChIP-chip and ChIP-seq and discover a GA-rich MSL recognition element (MRE). The motif is only slightly enriched on the X chromosome ( approximately 2-fold), but this is doubled when considering its preferential location within or 3' to active genes (>4-fold enrichment). When inserted on an autosome, a newly identified site can direct local MSL spreading to flanking active genes. These results provide strong evidence for both sequence-dependent and -independent steps in MSL targeting of dosage compensation to the male X chromosome. 相似文献
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Gwendal Le Martelot Donatella Canella Laura Symul Eugenia Migliavacca Federica Gilardi Robin Liechti Olivier Martin Keith Harshman Mauro Delorenzi Béatrice Desvergne Winship Herr Bart Deplancke Ueli Schibler Jacques Rougemont Nicolas Guex Nouria Hernandez Felix Naef the CycliX consortium 《PLoS biology》2012,10(11)