应用Fourier变换对东北地区成人颅骨性别差异的研究

本研究所用材料为已知性别、已知年龄的东北地区汉族成人干燥颅骨。应用Fourier变换,将额骨矢状弧的形态转变成Fourier极数,然后应用多元逐步判别分析求得性别判别函数,判别符合率达到90.10％。对31例已知性别汉族成人颅骨盲测,正确率达到84.21% (男性) 和83.33％ (女性) 。研究表明,颅骨的大小和年龄对本方法的判别结果无显著影响。     

结合改进卷积神经网络和最小二乘法的颅骨性别鉴定

颅骨性别鉴定在法医学和颅骨面貌复原等领域具有重要研究意义和应用价值,针对传统颅骨性别鉴定需要专家参与且主观性强、计算机辅助方法需要人工标定特征点等问题,本文提出了结合改进卷积神经网络和最小二乘法的颅骨性别鉴定方法。首先,获取三维颅骨模型多角度颅骨图像,利用改进的卷积神经网络计算每个样本的每张图像属于男性和女性的概率;其次,基于概率均值采用最小二乘法计算每张图像对性别鉴定的权重;最后,利用上述步骤得到的最优参数构造决策函数,通过决策值完成颅骨性别鉴定。本文方法抛弃了繁琐的手动测量,对完整颅骨的性别鉴定正确率高达94.4%,对不完整颅骨的性别鉴定正确率高达87.5%,能够获得较好的颅骨性别鉴定性能。     

青岛汉族颅骨某些角度的测量(续)

本文对青岛地区出土的已知性别成人颅骨312例(男154、女158)进行了十七个角度的测量,并按测量结果对颅骨某些角度的性差进行了讨论。     

人类颅骨厚度研究的概述与展望

颅骨厚度是重要的解剖学特征，也是常见的测量项目，在体质人类学研究中具有重要意义。目前关于颅骨厚度的研究主要集中在颅骨厚度的年龄与时代变化、人群间和性别间的差异、颅骨厚度的影响因素和与力学性能的关系等几个方面。颅骨厚度的相关研究有助于我们更为全面地了解人类颅骨的形态变异和进化情况。国内对颅骨厚度的关注相对较少，本文通过梳理和归纳已有关于颅骨厚度研究的相关文献数据与结论，对颅骨厚度相关研究进展及其测量方法进行了概述，并对国内颅骨厚度研究作了简要回顾和展望。     

青岛出土颅骨某些径的测量

对国人颅骨径的测量已不少见,但多为依据骨骼人类学性别特征进行性别鉴定、或未经性别鉴定的材料,而对已知生前性别者的测量并不甚多,为了积累国人体质材料,并为人类学、解剖学及法医学等研究提供参考依据,我们按《人体骨骼测量方法》（吴汝康等,1965）和《人体测量手册》（邵象清,1985）等所列标准为主要依据,对青岛出土、已知性别（据墓碑记载）、多为汉族、较完整的312例（男154,女158）成人颅骨进行了十四项径的直线测量,对所测数据进行了统计学处理和性别差异检验。现将主要结果列于上页表。     

太行山猕猴颅骨变量的波动不对称性

探讨了太行山猕猴Macaca mulatta颅骨变量波动不对称特征及影响因素。猕猴颅骨标本62例(♀43,♂19),按性别和年龄分组。选择颅骨两侧对称的24个变量,转换为标准波动不对称值(FA)。数据用SPSS 20.0进行处理。结果显示:大部分颅骨变量的FA值在性别组间和年龄组间没有统计学差异(P>0.05);不同变量的FA值大小不同;FA值的变化趋势是雌性大于雄性,亚成体组大于成体组。结果提示猕猴颅骨波动不对称特征可能与它们的肢骨不对称特征不同,可能在某种程度上反映了猕猴的生长发育及环境刺激对不对称的影响。     

深圳福田红树林弧边招潮蟹觅食行为的研究

为了研究深圳福田红树林自然保护区弧边招潮蟹Uca arcuata 的觅食行为特征, 于2013 年7-9 月在凤塘河码头、2 号鱼塘潮沟、3 号鱼塘潮沟, 借助望远镜观察了弧边招潮蟹的进食行为、边走边食行为和进食速率。共观察了673 只弧边招潮蟹的进食、边走边食行为和519 只弧边招潮蟹的进食速率, 结果表明: 弧边招潮蟹在5min 的观察期内用于进食和边走边食上的时间比例分别是42.27%、26.99%, 平均进食速率为50.44 次·min–1。生境、时间、性别均对弧边招潮蟹的进食行为有显著影响, 生境对边走边食行为有显著影响, 生境和性别对进食速率有极显著影响。弧边招潮蟹的觅食行为特征可以反映水质的污染状况。实验丰富了弧边招潮蟹的研究、有助于更深入全面的了解红树林生态系统, 也对今后红树林的管理和保护具有一定的帮助。     

太行山猕猴颅骨变量的异速生长研究

采用定点方法 ,对太行山猕猴 (Macacamulatta)颅骨的 3 2项变量进行了测量、统计和异速生长分析 ,结果表明 ,除颅骨最小宽和冠颞点间宽外 ,其余变量统计值雄性大于雌性 ;颅骨变量的生长存在性别间及部位间的差异。这些差异与雄性和雌性在社群中的不同地位和竞争压力以及取食习性有关。     

青岛汉族颅骨某些角度的测量

1.本文对青岛地区出土的已知性别成人颅骨304例(男153,女151)进行了十六项角度的测量,并按测量结果进行了分型。 2.讨论了颅骨某些角的性别差异。 3.将所测结果与湖南资料进行了比较,发现多无差异,可能与同为汉族有关。     

男性特小颅一例报告

本例特小颅T1的死者为男性,年龄约40岁,身高168cm,中国人。经颅骨各项指标测量和观察,该颅骨的脑颅特小,尤其是额部特别窄小;而面颅则相对较大,上、下颌骨向前突出。颅骨主要的长、宽、高各径和弧、弦、周长等的测量值均比其他报道中的最小值要小;颅容量为602ml,比已报道的最小颅容量1340ml还要小一倍多,故将其称为特小颅。     

Covalently linking the Escherichia coli global anaerobic regulator FNR in tandem allows it to function as an oxygen stable dimer

Glutathione (GSH) serves as an important anti-oxidant in the brain by scavenging harmful reactive oxygen species that are generated during different molecular processes. The GSH level in the brain provides indirect information on oxidative stress of the brain. We report in vivo detection of GSH non-invasively from various brain regions (frontal cortex, parietal cortex, hippocampus and cerebellum) in bilateral hemispheres of healthy male and female subjects and from bi-lateral frontal cortices in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). All AD patients who participated in this study were on medication with cholinesterase inhibitors. Healthy young male (age 26.4±3.0) and healthy young female (age 23.6±2.1) subjects have higher amount of GSH in the parietal cortical region and a specific GSH distribution pattern (parietal cortex>frontal cortex>hippocampus ~ cerebellum) has been found. Overall mean GSH content is higher in healthy young female compared to healthy young male subjects and GSH is distributed differently in two hemispheres among male and female subjects. In both young female and male subjects, statistically significant (p=0.02 for young female and p=0.001 for young male) difference in mean GSH content is found when compared between left frontal cortex (LFC) and right frontal cortex (RFC). In healthy young female subjects, we report statistically significant positive correlation of GSH content between RFC and LFC (r=0.641, p=0.004) as well as right parietal cortex (RPC) and left parietal cortex (LPC) (r=0.797, p=0.000) regions. In healthy young male subjects, statistically significant positive correlation of GSH content was observed between LFC and LPC (r=0.481, p=0.032) regions. This statistical analysis implicates that in case of a high GSH content in LPC of a young male, his LFC region would also contain high GSH and vice versa. The difference in mean of GSH content between healthy young female control and female AD patients in RFC region (p=0.003) and difference in mean of GSH content between healthy young male control and male AD patients (p=0.05) in LFC region is found to be statistically significant. It is the first scientific report correlating alteration (in selective brain regions) of GSH level with clinical status of male and female subjects using non-invasive imaging technique.     

现代人头骨断面轮廓的性别鉴定——基于几何形态测量的研究

人类头骨在大小、粗壮度和形状上具有性别差异。长期以来,性别鉴定的方法主要是根据头骨的大小和粗壮度,用肉眼进行粗略观察。受研究方法的限制,忽略了头骨细微的解剖结构及形状差别。为获取头骨性别差异的更多信息,探究头骨断面轮廓的性别差异,本文选用距今300年左右墓葬出土的云南现代人成年男性和女性头骨各30例作为研究材料,利用3D激光扫描技术及逆向工程软件提取头骨断面的外轮廓信息,在此基础上,采用几何形态测量方法对头骨冠状面、矢状面的外轮廓形状的性别差异进行了比较。研究结果显示:男女头骨在冠状面、正中矢状面顶骨部、正中矢状面枕骨部的形状上性别差异不显著,而在正中矢状面额骨部的形状上差异显著。本文对于古人类学和体质人类学鉴定人类头骨的性别差异,以及探讨不同地区、不同时代人群头面部形状的变异具有一定的参考价值。     

黑水国遗址汉代人群的上颌窦炎症

上颌窦是位于鼻腔周围最大的骨质腔,由于其所处位置及结构的特殊性,相比额窦、筛窦、蝶窦,上颌窦更容易受到感染产生炎症反应,因此上颌窦炎是现代社会最常见的炎症性疾病之一。通过对黑水国遗址汉代人群上颌窦的观察,发现该墓地中有40.5%的个体上颌窦内出现骨形态的改变,以穗状骨片为主。女性上颌窦炎出现率远高于男性,但无统计学上的显著差异,男性上颌窦炎左侧出现率高于右侧,女性右侧高于左侧。按照不同的年龄段划分,从未成年期到中年期上颌窦炎的出现率随着年龄的增长而增长,但是通过二元逻辑回归检验,发现上颌窦炎与年龄之间并无统计学上的显著意义。在患有上颌窦炎的个体中,有66.7%的个体都出现了牙周病,一半以上的个体出现了龋齿。这似乎预示着上颌窦炎与牙齿疾病之间有着一定的联系。张掖黑水国遗址汉代人群上颌窦炎的高出现率可能是多因素导致的结果,包括寒冷干燥的气候环境、空气污染、牙齿疾病以及病原微生物等。     

华北人欧洲人和澳洲土著人的头骨厚度

The thickness of the cranial vault at the midline on the mid-frontal squama, pre-bregmatic einence, frontal at bregma, parietal at vertex, occipital at lambda and the external occipita1 protuberance was recorded in 40 male and 7 female Northern Chinese crania, 47 male and 52 female Australian Aboriginal crania and 13 male European crania using specially nodified vernier calipers. Comparison of vault thickness data obtained through direct measurement with those obtained fron lateral radiographs indicated that direct measurenent provided consistently more accurate results.
Male and fermale samples were processed separately so that the extent of sexbased variation could be examined.Student's t test was used to compare the sample means and the percentage of sexual dimorphism for each dimension was calculated according to Garn et al, (1964).The possibility of an allometric association between the thickness of the bones within the cranial vault, size of the cranial vault and stature was examined using Spearman's rank correlation coefficient and the Australian Aboriginal sample.
All but one of the mean thickness dimensions in the Australian Aboriginal male sample is significantly greater than the Northern Chinese and European means. The female results support those obtained with the males.In both males and females thickness at the external occipital protuberance, in all of the populations examined,did not correlate highly with that obtained from other parts of the cranial vault.This reflects the high degree of morphological variation in the position of the internal occipital protuberance and its influence on cranial vault thickness dimensions recorded at the external occipital protuberance.The European and Northern Chinese samples have similar cranial vault thickness dimensions. The Spearman's rank correlation coefficient matrix scores provide sone support for a biological association between vault thickness and overall cranial size. However, there appears to be little support for an association between stature and cranial vault thickness. The difference between the male and female mean vault thickness dimensions were significant at bregma, vertex and the external occipital protuberance in Australian Aboriginals and lambda and the external occipital protuberance in Northern Chinese. Some caution is needed in the interpretation of the Northern Chinese female data as the sample is extremely small.
Evidence of trauma, supressed fractures, is extremely common on the vaults of Australian Aboriginal crania from southern and central Australia. Traditionally Australian Aboriginals, males and females, involved in agressive dispute will use a substantial wooden implement and strike to the head of thir opponent(Meggitt 1962).The injuries that result from this are more common in females than in male. This form of social interaction must have rigorously selected against those individuals with thinner bones in their cranial vaults. To a large degree this may explain the greatly thickened vaults in Australian Aboriginals relative to Europeans and Northern Chines.This may also provide a clue to the factors resulting in the development of marked cranial vault thickness in Homo erectus.
     

香港地区现代人头骨的研究：性别和地区类型的判别分析

本文报告了香港地区现代中国人头骨测量性状的性别差异情况和香港与太原的男性头骨的差异情况。在此基础上,使用判别分析的方法建立了各自的判别函数,正判率分别达到93.1％和85.3％。它们分别适用于华南头骨的性别鉴定和华南与华北男性头骨的区分。     

近代人群头骨颞线的分型和变异

颞线作为头骨表面咀嚼肌颞肌的附着痕迹,其形态变异对探讨人类体质特征及咀嚼功能具有一定意义。为了解颞线在现代人群中的变异情况,本文选取亚洲、非洲和欧洲278例近现代成年人头骨为研究材料,通过对颞线的颞弧形态、宽度、发育程度、粗糙度及末端位置的观察和分析,明确颞线的分类及其定义标准,获取颞线各种表现形式的侧别、性别和地区间变异的数据,为体质人类学的研究提供参考资料。研究结果显示：1）颞线无显著侧别间差异;2）颞弧形态和发育程度无显著性别和地区间差异;3）顶部颞线宽度及粗糙度有显著性别间差异：男性顶部颞线整体较宽,粗糙型个体大多为男性;4）额部和顶部颞线宽度及粗糙度有显著地区间差异：超宽条带状颞线只出现在云南和华北地区标本,欧洲地区标本脊状颞线和粗糙型比例较高,非洲地区脊状颞线比例较高但粗糙型较低;5）颞线末端止于枕骨的类型极少;6）颞线宽度在额部和顶部及其与颞弧形态显著相关,颞线发育程度在额部与顶部显著相关。     

Endocranial cast of Hexian Homo erectus from South China

In this paper, we present data on the morphological features and linear measurements for the Hexian Homo erectus and other comparative endocasts, in order to highlight variation during human brain evolution. The endocast of Hexian was reconstructed in 1982, and an endocranial volume of 1,025 ml was estimated. The geological age is about 412 ka, or roughly contemporaneous with the Zhoukoudian (ZKD) specimens. There are some differences between Hexian and the modern Chinese male endocasts in our sample, including low position of the greatest breadth, low maximum height, a well-marked and prominent frontal keel, the flat surface of the frontal lobes, prominent sagittal keel along the center frontal and parietal lobes, depressed Sylvian areas and parietal lobes superiorly, strong posterior projection of the occipital lobes, anterior position of the cerebellar lobes relative to the occipital lobes, and the relative simplicity of the meningeal vessels. Compared with the ZKD, Indonesian, and African Homo erectus specimens, Hexian has more morphological features in common with ZKD. Principal component analyses indicate that Hexian is closest to the ZKD Homo erectus compared with the modern Chinese and other Homo erectus, but its great breadth distinguishes it. Metric analyses show that the brain height, frontal breadth, cerebral height, frontal height, and parietal chord from Homo erectus to modern humans increased, while the length, breadth, frontal chord, and occipital breadth did not change substantially.     

Activation of FGF signaling mediates proliferative and osteogenic differences between neural crest derived frontal and mesoderm parietal derived bone

Background

As a culmination of efforts over the last years, our knowledge of the embryonic origins of the mammalian frontal and parietal cranial bones is unambiguous. Progenitor cells that subsequently give rise to frontal bone are of neural crest origin, while parietal bone progenitors arise from paraxial mesoderm. Given the unique qualities of neural crest cells and the clear delineation of the embryonic origins of the calvarial bones, we sought to determine whether mouse neural crest derived frontal bone differs in biology from mesoderm derived parietal bone.

Methods

BrdU incorporation, immunoblotting and osteogenic differentiation assays were performed to investigate the proliferative rate and osteogenic potential of embryonic and postnatal osteoblasts derived from mouse frontal and parietal bones. Co-culture experiments and treatment with conditioned medium harvested from both types of osteoblasts were performed to investigate potential interactions between the two different tissue origin osteoblasts. Immunoblotting techniques were used to investigate the endogenous level of FGF-2 and the activation of three major FGF signaling pathways. Knockdown of FGF Receptor 1 (FgfR1) was employed to inactivate the FGF signaling.

Results

Our results demonstrated that striking differences in cell proliferation and osteogenic differentiation between the frontal and parietal bone can be detected already at embryonic stages. The greater proliferation rate, as well as osteogenic capacity of frontal bone derived osteoblasts, were paralleled by an elevated level of FGF-2 protein synthesis. Moreover, an enhanced activation of FGF-signaling pathways was observed in frontal bone derived osteoblasts. Finally, the greater osteogenic potential of frontal derived osteoblasts was dramatically impaired by knocking down FgfR1.

Conclusions

Osteoblasts from mouse neural crest derived frontal bone displayed a greater proliferative and osteogenic potential and endogenous enhanced activation of FGF signaling compared to osteoblasts from mesoderm derived parietal bone. FGF signaling plays a key role in determining biological differences between the two types of osteoblasts.     

Cranial thickness of modern and neolithic populations in Japan

Cranial vault thicknesses were measured directly with a spreading caliper at six anatomical reference points in the modern Japanese and Neolithic Jomon series. Because no statistically significant correlation was found between age and cranial thickness in our study, the age-related change in thickness was not indicated in the modern Japanese. The cranial thicknesses at the frontal and parietal eminences were significantly greater in the female than in the male in modern Japanese. In the male series the cranial thickness of the Neolithic Jomon was significantly greater than that of modern Japanese. It is suggested that the temporal change that has occurred in Japan during the last 2000 years is consistent with the trend toward decreasing cranial thickness during the last 10,000 years in many parts of the world.