柳叶白前化学成分研究

从柳叶白前根和茎中分离并鉴定了7个化合物,分别为β-谷甾醇（β-sitosterol,1）,2,4-二羟基苯乙酮（1-（2,4-dihydroxphenyl）ethanone,2）,间二苯酚（resorcinol,3）,4-羟基-3-甲氧基苯乙酮（1-（4-hydroxy-3-methoxyphenyl）e-hanone,4）,4-羟基苯乙酮（1-（4-hydroxyphenyl）ethanone,5）,齐墩果酸（oleanolic acid,6）,蔗糖（sucrose,7）。其中化合物2-7为首次从该植物中分得。     

星状凤毛菊的化学成分研究

采用各种填料的色谱柱层析方法从药用植物星状凤毛菊(Saussurea stella Maxim)的全草中分离纯化出15个化合物,经波谱分析将它们的化学结构分别鉴定为2-甲氧基-4-羟基苯甲醛(1)、3-(3-甲氧基苯基)丙烯醛(2)、松脂素-4′-O-β-葡萄糖苷(3)、胡萝卜苷(4)、木犀草素(5)、金合欢素(6)、洋芹素(7)、日本椴苷(8)、3′-甲氧基木犀草素-7-O-β-葡萄糖苷(9)、洋芹素-7-O-β-葡萄糖苷(10)、槲皮素-3-O-α-L-鼠李糖苷(11)、山奈素3-O-α-L-鼠李糖苷(12)、槲皮素-5-O-β-葡萄糖苷(13)、4′-甲氧基槲皮素-5-O-β葡萄糖苷(14)和3-甲氧基山奈素-6-O-β葡萄糖苷(15)。其中化合物1～5、9～10和13～15是首次从该种植物中分离得到。     

无梗五加根中苯丙素类化合物的研究

从无梗五加(Acanthoparax sessiliflorus( Rupr.et Maxim.)Seem.)根70％乙醇提取物的乙酸乙酯层中提取分离得到8个苯丙素类化合物.经理化和波谱分析鉴定为(+)-表芝麻脂素(1)、(-)-芝麻脂素(2)、赛菊芋黄素(3)、洒维宁(4)、咖啡酸甲酯(5)、对羟基桂皮酸(6)、(-)-丁香脂素(7)、(+)-松脂索(8).化合物8是首次从五加科植物中分离得到,化合物1和5是首次从五加属植物中分离得到,化合物3、6和7是首次从该植物中分离得到.     

荔枝草抗氧化部位的化学成分研究

目的:研究荔枝草抗氧化部位的化学成分及单体化合物的抗氧化活性.方法:采用HP-20大孔树脂、硅胶、Sephadex LH-20及中压制备等手段,对荔枝草抗氧化部位进行分离纯化.根据理化性质和核磁、质谱数据解析化合物的结构;采用清除DPPH自由基和还原力实验测试总黄酮和单体化合物的抗氧化能力.结果:分离得到5个黄酮类化合物:楔叶泽兰素(1),高车前素(2),高车前苷(3),假荆芥属苷(4),5,7,4’-三羟基-6-甲氧基-二氢黄酮-7-O-β-D-葡萄糖苷(5)和2个苯丙素类化合物:咖啡酸(6)和迷迭香酸(7);抗氧化活性研究表明总黄酮和化合物均具有明显的抗氧化活性.结论:化合物5首次从野生荔枝草中分离得到,化合物7首次从该属分离得到;系统地分析了提取物和组分的抗氧化活性.     

鹧鸪花中一个新的木脂素

为明确鹧鸪花枝叶的化学物质基础，该研究采用硅胶柱色谱、MCI、C₁₈、Sephadex LH-20及制备HPLC等色谱技术对其进行分离和纯化，并通过理化性质和波谱数据鉴定化合物的结构。结果表明：(1)从鹧鸪花枝、叶的甲醇提取物中分离得到6个单体化合物，分别鉴定为新化合物8-O-4′-木脂素，即heynealigan A(1)、3β,21-dihydroxy-24-methylenecycloartane(2)、3-oxo-threo-23,24,25-trihydroxytirucall-7-ene(3)、16-dehydeoxy-23β-hydroxymeliasenin F(4)、ergost-5, 24(28)-diene-3β, 23S-diol(5)、7α-羟基谷甾醇(6)。(2)化合物1为新的木脂素，化合物2-4为三萜化合物，化合物5和化合物6为甾体化合物，化合物2-5为首次从该植物中分离得到。该研究结果为鹧鸪花的合理开发利用提供了科学依据。     

藏药翁布的黄酮类化学成分研究

从藏药翁布(Myricaria germanica)的60%丙酮提取物中分离得到了11个黄酮类化合物,利用光谱、波谱分析法鉴定其结构分别为:35,,4’-三羟基-73,’-二甲氧基黄酮(1),3,5,4’-三羟基-7-甲氧基黄酮(2),3,5,3’,4’-四羟基-7-甲氧基黄酮(3),35,7,-三羟基-4’-甲氧基黄酮(4),柽柳素(5),山柰酚(6),槲皮素-3-O-β-D-葡萄糖苷(7)5,,7,4’-三羟基-3-O-β-D-葡萄糖醛酸(8),5,7,3’4,’-四羟基-3-O-β-D-葡萄糖醛酸(9),槲皮苷(10)和阿福豆苷(11)。上述化合物均为首次从该植物中分离得到,其中化合物4、5、7～11为首次从水柏枝属植物中分离得到。     

刺五加果肉化学成分的研究

应用多种色谱技术进行分离纯化,从刺五加果肉水提取物中分离得到10个化合物,经理化性质和波谱分析鉴定其结构分别为左旋芝麻脂素(1)、紫丁香树脂酚(2)、6,7-二甲氧基香豆素(3)、7-羟基-6-甲氧基香豆素(4)、儿茶酚(5)、芦丁(6)、12-羟基硬脂酸(7)、豆甾醇(8)、β-谷甾醇(9)和蔗糖(10)。化合物3、4、5、7和8为首次从该植物中分得,其中化合物7为新的天然产物。     

元宝草中一个新的二苯甲酮

为了研究元宝草(Hypericum sampsonii Hance)全草的化学成分,利用硅胶柱层析、Sephadex LH-20等色谱技术对元宝草三氯甲烷部位进行分离和纯化,共得到6个化合物,通过1H NMR、13C NMR、HMQC、HMBC等波谱技术分别鉴定为2,6-二羟基-4,3’,5’-三甲氧基二苯甲酮(1)、1,3,6-三羟基-2-甲基蒽醌(2)、山奈酚(3)、木犀草素(4)、3,4-二羟基苯甲酸乙酯(5)、β-谷甾醇(6),其中化合物1为新化合物,化合物2和5首次从该植物中分离得到。     

青蕨化学成分的研究

从青蕨的乙酸乙酯提取物中分离得到6个化合物,通过化学方法及波谱分析,分别将其结构鉴定为木香素Ⅲ(1),7-甲氧基鬼灯擎素(2),扶桑甾醇(3),5-(3′-甲基丁基)-8-甲氧基呋喃香豆素(4),2-(3′-羟基-3′-甲基)丁基-4-羟基-5-甲氧基苯酚-1-O-β-D匍吡喃糖苷(青蕨素Ⅰ)(5)和2-(3′-羟基-3′-甲基)丁基-4-羟基-3,6-二甲氧基苯酚-1-O-β-D-匍吡喃糖苷(青蕨素Ⅱ)(6)。化合物5和6为新化合物,化合物1,2,3和4为首次从该植物中分离得到。     

连香树树皮化学成分的研究

从连香树（CercidiphyllumjaponicumSieb.etZucc.）树皮中分离到8个化合物。其中7个为黄酮醇,l个为酚酸类成分。经理化测定和波谱解析,分别鉴定为：5,7-二羟基-3,8,4'-三甲氧基黄酮（Ⅰ）、3,5,7-三羟基-8,4'-二甲氧基黄酮（Ⅱ）、5,7,4'-三羟基-3,8-二甲氧基黄酮（Ⅲ）、3,5,7,4'-四羟基-8-甲氧基黄酮（Ⅳ）、3,5,7,4'-四羟基黄酮（Ⅴ）、5,7-二羟基-8,4'－二甲氧基黄酮-3-O-葡萄糖甙（Ⅶ）、5,7,4'-三羟基-8-甲氧基黄酮-3－O-葡萄糖甙（Ⅷ）和没食子酸乙酯（Ⅵ）。其中化合物Ⅶ为未见报道的新化合物。除化合物Ⅴ外,其余化合物均为首次从该属植物中分得。     

4-Carboxy-4-hydroxy-2-aminoadipic acid and other acidic amino acids in Caylusea abyssinica

Two diastereoisomers of 4-carboxy-4-hydroxy-2-aminoadipic acid have been isolated from leaves and inflorescences of Caylusea abyssinica. Green parts of the plant also contain appreciable amounts of the two diastereoisomers of 4-hydroxy-4-methylglutamic acid, 3-(3-carboxyphenyl)alanine, (3-carboxyphenyl)glycine, 3-(3-carboxy-4-hydroxyphenyl)alanine, (3-carboxy-4-hydroxyphenyl)glycine and in low concentration 2-aminoadipic acid, saccharopine [(2S, 2′S)-N⁶-(2-glutaryl)lysine] and some γ-glutamyl peptides. The acidic amino acids were separated from other amino acids on an Ecteola ion exchange column with M pyridine as eluant.     

团花树皮的化学成分研究

采用硅胶、MCI和Sephadex LH-20层析方法对团花树皮的化学成分进行分离纯化,运用现代波谱技术鉴定了10个化合物:4-carboxy-3-hydroxy-5-methylphenyl 3-methoxy-4-hydroxy-5-methylbenzoate(1),谷甾醇-3-O-(6’-O-棕榈酰基)-β-D-葡萄糖苷(2),喹诺酸-3-O-α-L-鼠李糖苷(3),clethric acid(4),常春藤苷元(5),钩藤苷元C(6),morolic acid(7),咖啡酸甲酯(8),卡丹宾(9)和3α-二氢卡丹宾(10)。其中化合物1为一个新的酚性成分,化合物2～8首次从该属植物中分离得到。     

Hydroxylated jasmonic acid and related compounds from Botryodiplodia theobromae

From the culture filtrate of the fungus Botryodiplodia theobromae five hydroxylated cyclopentane fatty acids of the jasmonic acid type were isolated and identified as (11 S -(-)-hydroxyjasmonic acid; (11R)-(-)-hydroxyjasmonic acid; (-)-12-hydroxyjasmonic acid; (-)-8ξ-hydroxyjasmonic acid; (-)-3-oxo-2-(1ξ-hydroxy-2Z-pentenyl)cyclopent-1-yl-butyric acid; (-)-3-oxo-2(4ξ-hydroxy-2Z-pentenyl)cyclopent-1-yl-butyric acid. In addition, the corresponding hydroxylated iso-jasmonic acid analogues were found as minor constituents. During silica gel chromatography 11,12-didehydrojasmonic acid, 11ξ-acetoxyjasmonic acid, 3-oxo-2-(4ξ-acetoxy-2Z-pentenyl)cyclopent-1-yl-butyric acid 3-oxo-2-(2Z,4-pentadienyl)cyclopent-1-yl-butyric acid were formed as artefacts.     

根霉3078的代谢产物的研究

从根霉3078菌丝体的甲醇提取物中分离得到9个化合物,通过波谱分析,鉴定为5α,8α-表二氧-(20S,22E,24R)-麦角甾-6,22-二烯-3β-醇(1)、甘油醇-1-单油酸酯(2)、4-羟基苯乙酮(3)、4-羟基苯乙酸(4)、(20S,22E,24R)-麦角甾-7,22-二烯-3β,5α,6β三醇(5)、(S)-3-羟基-3-苯基丙酸(6)、胸腺嘧啶(7)、尿嘧啶(8)和腺苷(9)。     

Acidic amino acids in Reseda luteola

3-(3-Carboxyphenyl)alanine, (3-carboxyphenyl)glycine, 3-(3-carboxy-4-hydroxyphenyl)alanine and (3-carboxy-4-hydroxyphenyl)glycine occur in all parts of Reseda luteola. The concentrations of the two diastereoisomers of 2(S)-4-hydroxy-4-methylglutamic acid undergo seasonal variation, the highest concentrations occurring in the first part of the summer. Highest concentrations are found in the inflorescences. The two diastereoisomers of 2(S)-4-hydroxy-2-aminopimelic acid occur in appreciable amounts in all parts of the plant. They are easily transformed into two structurally different lactones, one of which is very unstable. The structures of these amino acids have been confirmed by synthesis. Green parts of R. luteola also contain substantial quantities of γ-glutamylglutamic acid and glutathione.     

Constitutions of diarylpropanoids from Virola multinervia

The wood of Virola multinervia Ducke (Myristicaceae) contains sitosterol, stigmasterol and two novel diarylpropanoids virolane [1-(2-hydroxy-4-methoxyphenyl)-3-(3,4-methylenedioxyphenyl)-propane] and virolanol [2-hydroxy-1-(2-hydroxy-4-methoxyphenyl)-3-(3,4-methylenedioxyphenyl)-propane].     

A substituted 1,2-diarylethane from Cymbidium giganteum

In addition to sitosterol and taraxerone, a new substituted 1,2-diarylethane, gigantol has been isolated from Cymbidium giganteum and characterized as 1-(3′-hydroxy-5′-methoxyphenyl-2-(4″-hydroxy-5″-methoxyphenyl)ethane on the basis of physicochemical data and through synthesis of its derivative.     

A pungent diarylheptanoid from Alpinia oxyphylla

From the neutral fraction of the methanolic extract of the fruit of Alpinia oxyphylla, a new pungent compound has been isolated, and is shown to be 1-(4′-hydroxy-3′-methoxyphenyl)-7-phenyl-3-heptanone. This compound is 125 times more pungent than zingerone.     

Lactones,flavonoids and benzophenones from Garcinia conrauana and Garcinia mannii

Two novel lactones have been isolated from the stem barks of Garcinia conrauana and G. mannii. The major component of the bark of G. conrauana was identified as 3-(3$\text{,}\text{?}$ 3″-dimethylallyl)-conrauanalactone [4-hydroxy-3-(3″, 3″-dimethylallyl)-6-pentadecylpyran- 2-one] by comparison of spectral data of the isolated compound and two methylethers with that obtained for the previously isolated conrauanalactone. A minor component of the bark of G. mannii was tentatively identified as 3-α-hydroxy-5-(heptadec-8′-enyl)-tetrahydro- furan-2-one on the basis of spectral data from the isolated compound and its monoacetate. The distributions of biflavonoids and related compounds and benzophenones in the stem bark, heartwood, seeds and leaves of the two species are reported.     

A pungent principle from Alpinia oxyphylla

A pungent diarylheptanoid isolated from Alpinia oxyphylla has been characterized as trans-1-(4′-hydroxy-3′-methoxyphenyl)-7-phenylhept-1-en