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With multiple divisions in culture, normal diploid cells suffer a loss of growth potential that leads to replicative senescence and a finite replicative capacity. Using quantitative RT-PCR, we have monitored mRNA expression levels of c-fos, c-jun, JunB, c-myc, p53, H-ras, and histone H4 during the replicative senescence of human fibroblasts. The earliest and the largest changes in gene expression occurred in c-fos and junB at mid-senescence prior to the first slowing in cell growth rates. The basal level of c-fos mRNA decreased to one-ninth that of the early-passage levels, while junB declined to one-third and c-jun expression remained constant. The decline in the basal c-fos mRNA level in mid-senescence should lead to an increase in Jun/Jun AP-1 homodimers at the expense of Fos/Jun heterodimers and may trigger a cascade of further changes in c-myc, p53, and H-ras expression in late-passage senescent fibroblasts. 相似文献
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Transcriptional regulation of the transforming growth factor beta 1 promoter by v-src gene products is mediated through the AP-1 complex. 总被引:7,自引:5,他引:2 下载免费PDF全文
M C Birchenall-Roberts F W Ruscetti J Kasper H D Lee R Friedman A Geiser M B Sporn A B Roberts S J Kim 《Molecular and cellular biology》1990,10(9):4978-4983
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Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex. 总被引:43,自引:9,他引:34 下载免费PDF全文
S J Kim P Angel R Lafyatis K Hattori K Y Kim M B Sporn M Karin A B Roberts 《Molecular and cellular biology》1990,10(4):1492-1497
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B Rana D Mischoulon Y Xie N L Bucher S R Farmer 《Molecular and cellular biology》1994,14(9):5858-5869
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Estrogen stimulates transcription of c-jun protooncogene 总被引:6,自引:0,他引:6
A Weisz L Cicatiello E Persico M Scalona F Bresciani 《Molecular endocrinology (Baltimore, Md.)》1990,4(7):1041-1050
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