| 维吾尔药神香草调节哮喘大鼠下丘脑-垂体-肾上腺轴功能紊乱的实验研究 |
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| 引用本文： | 薛志琴,马雪萍,徐琦,王晶,马秀敏,丁剑冰.维吾尔药神香草调节哮喘大鼠下丘脑-垂体-肾上腺轴功能紊乱的实验研究[J].现代生物医学进展,2011,11(22):4222-4224. |
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| 作者姓名： | 薛志琴 马雪萍 徐琦 王晶 马秀敏 丁剑冰 |
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| 作者单位： | 1. 新疆医科大学基础医学院
2. 新疆医科大学附属中医医院 新疆乌鲁木齐830011 |
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| 基金项目： | 新疆维吾尔自治区高校科研计划项目(XJEDU2009S50);新疆维吾尔自治区高校科研计划项目(XJEDU2008117); 新疆维吾尔自治区自然科学基金(200821129) |
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| 摘 要： | 目的:观察维吾尔药(维药)神香草对哮喘大鼠模型神经内分泌免疫网络若干组分的影响。方法:取雄性健康Wistar大鼠50只,随机分为正常对照组,哮喘模型组,神香草低、中、高剂量治疗组。采用致敏和雾化的方法制备哮喘模型。采用酶联免疫吸附试验(ELISA)方法检测血清中白介素-4(IL-4)、白介素-6(IL-6)、干扰素-γ(IFN-γ)、皮质酮(CORT)水平;放免法检测血浆中促肾上腺皮质激素(ACTH)的含量;采用实时定量-聚合酶链反应(RT-PCR)法测定下丘脑促肾上腺皮质激素释放激素(CRH)mRNA表达水平。结果:哮喘反复发作时,大鼠下丘脑-垂体-肾上腺(HPA)轴紊乱,哮喘大鼠下丘脑CRH mRNA表达和血浆ACTH无明显变化,实验各组血清CORT水平升高(P<0.05),神香草高剂量组血清CORT含量高于低剂量组(P<0.05)。细胞因子IFN-γ无明显变化,IL-6、IL-4有下降趋势(P<0.05)。结论:哮喘反复发作的大鼠存在NEI网络的紊乱;神香草可以增强下丘脑-垂体-肾上腺皮质(HPA)轴的功能,改善细胞因子的平衡。这些可能是其治疗哮喘的机制之一。
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| 关 键 词： | 维药神香草 哮喘 神经内分泌免疫网络 下丘脑-垂体-肾上腺轴 |
The Effects of Uygur Herb Hyssopus officinalis L.on the Hypothalamic-Pituitary-Adrena Axis Dysfunction of Asthmatic Rats |
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| XUE Zhi-qin,MA Xue-ping,XU Qi,WANG Jing,MA Xiu-min,DING Jian-bing.The Effects of Uygur Herb Hyssopus officinalis L.on the Hypothalamic-Pituitary-Adrena Axis Dysfunction of Asthmatic Rats[J].Progress in Modern Biomedicine,2011,11(22):4222-4224. |
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| Authors: | XUE Zhi-qin MA Xue-ping XU Qi WANG Jing MA Xiu-min DING Jian-bing |
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| Affiliation: | XUE Zhi-qin1,MA Xue-ping1,XU Qi1,WANG Jing2,MA Xiu-min1,DING Jian-bing1(1 Preclinical Medical College,2 Traditional Chinese Medicine Hospital,Xinjiang Medical University,Urumqi,Xinjiang,830011,China) |
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| Abstract: | Objective: To evaluate the effect of Uygur herb hyssopus officinalis L.on the neuro-endocrine-immune(NEI) network in asthmatic rats.Methods: Asthma model was established by oval albumin sensitization and long-term excitation.Fifty healthy SD rats were randomly divided into 5 groups by randomized digital table,the control group,the asthma model group and other three groups treated by low,moderate and high dose of hyssopus officinalis L.,respectively.Blood content of adrenocorticotrophic hormone(ACTH) was det... |
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| Keywords: | Hyssopus officinalis L Bronchial asthma Neuro-endocrine-immune network Hypothalamic-pituitary-adrenal axis |
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