The commercial planting of insect-resistant genetically modified (IRGM) crops has greatly benefited the economy, ecology and society. Risk assessment of IRGM crops has been a focus of researchers worldwide. A new IRGM variety must be subjected to a rigorous pre-market risk assessment before it is commercially grown, and an evaluation of potential adverse effects on valued non-target organisms is an important part of the risk assessment process. Ladybugs are dominant non-target predators in agroecosystems, and their chronic exposure to Bt proteins when feeding on pollen or preying on other insects in IRGM crops can lead to environmental risk. Thus, evaluating the potential adverse effects of IRGM crops on ladybugs is of great importance. Here, we reviewed the progress on assessing the ecological effects of IRGM crops on predatory ladybugs based on life table, behavioral function, field community, and internal microenvironment parameters. We have put forward suggestions for future research on assessing the risk of IRGM crops on the predators. Our paper could provide technical support and an experimental basis for developing a risk assessment of IRGM crops.