| Inflammatory bowel disease is a kind of chronic intestinal inflammatory disease, its etiology and pathogenesis are not clear, generally considered by the interactions of many factors such as intestinal mucosal immune regulation, persistent intestinal infection, intestinal mucosal barrier defect, heredity and environment. In recent years, studies have found that the level of IL-21 in the serum of patients with IBD is abnormally elevated, suggesting that IL-21/IL-21R signaling may play an important role in IBD. IL-21, an important cytokine with multiple biological functions, participates in the development of IBD by influencing many kinds of cells including CD4+T cells, CD8+T cells, Th17 cells, B cells, macrophages, dendritic cells. In this study, we will review the development of IL-21/IL-21R signaling in the pathogenesis of inflammatory bowel disease. |
