| 王星张东宪孙鹏宵侯巍郭海涛韩一生△.不同消毒方法对生物化PET 人工韧带的生物力学影响[J].,2012,12(12):2294-2297 |
| 不同消毒方法对生物化PET 人工韧带的生物力学影响 |
| Effect of Different Methods of Sterilization on Bio-Based PET MicroporousKnitted Artificial Ligament Biomechanical Properties |
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| DOI： |
| 中文关键词: 消毒 人工韧带 生物力学 聚对苯二甲酸乙二醇酯 |
| 英文关键词: Sterilization Artificial ligament Biomechanical Polyethylene terephthalate(PET) |
| 基金项目:国家自然科学基金资助项目（81071457） |
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| 中文摘要: |
| 目的：探讨环氧乙烷、高压蒸汽、60Co 照射三种消毒方法，对生物化PET 人工韧带的生物力学影响，为选取合适的消毒灭菌
方法提供实验依据。方法：以表面改性的聚对苯二甲酸乙二醇酯纤维为材料，制备生物化PET 人工韧带，分别给予环氧乙烷熏
蒸、高压蒸汽、60Co 照射消毒处理，并设未作消毒处理的空白对照组，分别进行生物力学测试，对测量结果行统计学比较分析。结
果：高压蒸汽消毒后，韧带所能承受的最大拉力及第一次破裂力降低，且与对照组间的差异均有统计学意义(P<0.05)；60Co 照射消
毒后，韧带所能承受的最大拉力降低，与对照组间的差异有统计学意义(P<0.05)，但第一次破裂力的差异不明显(P>0.05)；环氧乙
烷消毒处理后，最大拉力、第一次破裂力与对照组之间无明显差异(P>0.05)；各组间断裂伸长率无明显差异(P>0.05)。结论：高压蒸
汽消毒后韧带样品的生物力学性能降低比较明显；采用60Co 射线消毒方法对产品的力学性能影响较小，但进一步的消毒方法改
进可能更为理想；环氧乙烷消毒法可作为生物化PET 人工韧带的有效消毒方法。 |
| 英文摘要: |
| Objective: To investigate the effect of 60Co γ-ray irradiation sterilization,high-pressure steam sterilization and ethylene
oxide sterilization on bio-based PET microporous knitted artificial ligament biomechanical properties．Methods: Three treatment groups
of artificial ligaments were received ethylene oxide sterilization, high-pressure steam sterilization or 60Co-irradiation sterilization, while
control group have not received any kind of sterilization. All groups of artificial ligaments were conducted mechanics testing, then the date
of treatment groups compared with the control group. Results: There was no significant difference of biomechanical properties between
blank group and ethylene oxide group (P>0.05). However, compared with that in the control group, the ultimate tensile strength of
artificial ligament decreased significantly after being sterilized by 60Co-irradiation methord or by high-pressure steam methord (P<0.05).
What's more, the initial rupture strength of artificial ligament was significantly decreased after being sterilized by high-pressure steam
methord (P<0.05). Conclusions: As a sterilization agent, ethylene oxide was superior to 60Co-irradiation or high-pressure steam sterilization
on maintaining the biomechanical properties of artificial ligament. |
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