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Defining the biochemistry of mismatch repair
Affiliation:1. Marine Science & Technology Institute, College of Environmental Science and Engineering, Yangzhou University, China;2. Guangling College, Yangzhou University, China;3. Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, China;4. Univ Lyon, INSA De Lyon, CNRS UMR 5240, Lyon, France
Abstract:Following a period of intensive and illuminating genetic analysis, the biochemical mechanism of mismatch repair was deciphered by Paul Modrich and his colleagues. The establishment of an in vitro assay that specifically supports strand-specific excision repair of mismatched bases was a seminal contribution to this body of work.
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