Fermentative bioconversion in a horizontal rotating tubular bioreactor |
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| Affiliation: | 1. Department of Technology, University Centre of Naama, Po. Box 66, Naama, 45000, Algeria;2. Université Clermont Auvergne, Université Blaise Pascal, Institut Pascal, BP 10448, F-63000, Clermont-Ferrand, France;3. CNRS, UMR 6602, IP, F-63178, Aubière, France;1. Laboratorio de Reología, Departamento de Ingeniería Química, CUCEI, Universidad de Guadalajara, Blv. M. García Barragán 1421 Guadalajara, Jalisco, Mexico;2. Grupo de Física de Coloides y Polímeros, Departamento de Física de la Materia Condensada; Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain;3. School of Chemistry, University of Manchester, Manchester M13 9PL, United Kingdom;4. Servicio de Microbiología y Parasitología, Complejo Hospitalario de Santiago de Compostela, 15782 Santiago de Compostela, Spain;5. School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, United Kingdom;1. Institute of Physics and Beijing National Laboratory for Condensed Matter Physics, Chinese Academy of Sciences, Beijing 100190, China;2. Collaborative Innovation Center of Quantum Matter, Beijing 100190, China;3. School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100039, China;1. Department of Biotechnology, Delft University of Technology, Delft, The Netherlands;2. BE-Basic Foundation, Delft, The Netherlands;1. Institute of Mountain Hazard and Environment, CAS, Chengdu 610041, China;2. Key Laboratory of Mountain Surface Process and Ecological Regulation, CAS, Chengdu 610041, China;3. Australian-China Centre on Water Resources Research, University of Melbourne, Parkville 3010, Australia;4. University of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | The performance of a horizontal rotating tubular bioreactor (HRTB) was investigated with a biological system under non-sterile conditions. A spontaneously developed microbial culture was cultivated in a simple glucose/yeast extract medium. A fermentative bioconversion was examined by different combinations of process parameters (bioreactor rotation speed 5–30 min−1 and medium inflow rate 1–10 l h−1). Bioconversion dynamics in HRTB was monitored by withdrawing the samples from five positions along the bioreactor. Investigation in HRTB showed a rapid and an efficient glucose conversion into different products of metabolism. Glucose consumption rate along the HRTB depended on medium inflow rate, while bioreactor rotation speed did not have a significant influence. Complete glucose conversion in HRTB was observed at inflow rates of up to 6.5 l h−1. The pH gradient along the HRTB was detected at higher medium inflow rates (6.5 and 10 l h−1), but did not significantly influence substrate conversion efficiency. A discussion of its potential use and a comparison of HRTB with other bioreactors are also presented. |
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