Therapeutic potential of yeast killer toxin-like antibodies and mimotopes |
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| Affiliation: | 1. Sezione di Microbiologia, Dipartimento di Patologia e Medicina di Laboratorio, Università degli Studi di Parma, Viale Antonio Gramsci 14, 43100 Parma, Italy;2. Dipartimento di Biochimica e Biologia Molecolare, Parco Area delle Scienze, 23/A, 43100 Parma, Italy;1. Key Laboratory of Systems Biology, Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China;2. Bio-med Big Data Center, Key Laboratory of Computational Biology, CAS-MPG Partner Institute of Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China;3. Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China;4. Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China;5. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China;6. Guangdong Provincial Key Laboratory of Cell Microenviroment and Disease Research, Guangdong Provincial Key Laboratory of Computational Science and Material Design, Department of Biology, Southern University of Science and Technology, Shenzhen 518055, China;7. Laboratory of Systems Biology, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 200031, China;1. Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China;2. Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Sciences Center, Houston, TX, USA;1. Service de chirurgie plastique, reconstructrice et esthétique, CHU Croix-Rousse, 103, grande rue de la Croix-Rousse, 69004 Lyon, France;2. Service de chirurgie plastique, reconstructrice et esthétique, centre hospitalier universitaire vaudois, 21, rue du Bugnon, 1011 Lausanne, Suisse;3. Clinique Charcot, 69110 Sainte-Foy-les-Lyon, France;4. Cabinet privé, 50, rue de la République, 69002 Lyon, France;5. Centre Léon-Bérard, 28, rue Laennec, 69008 Lyon, France;1. Program of Biotechnology, Faculty of Science and Natural Resources, Universiti Malaysia Sabah, Kota Kinabalu, Malaysia;2. Program of Chemical Engineering, Faculty of Engineering Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia;3. Program of Chemical Industrial, Faculty of Science and Natural Resources, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia;4. Biotechnology Research Institute, Universiti Malaysia Sabah, Kota Kinabalu, Malaysia |
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| Abstract: | This review focuses on the potential of yeast killer toxin (KT)-like antibodies (KTAbs), that mimic a wide-spectrum KT through interaction with specific cell wall receptors (KTR) and their molecular derivatives (killer mimotopes), as putative new tools for transdisease anti-infective therapy. KTAbs are produced during the course of experimental and natural infections caused by KTR-bearing micro-organisms. They have been produced by idiotypic vaccination with a KT-neutralizing mAb, also in their monoclonal and recombinant formats. KTAbs and KTAbs-derived mimotopes may exert a strong therapeutic activity against mucosal and systemic infections caused by eukaryotic and prokaryotic pathogenic agents, thus representing new potential wide-spectrum antibiotics. |
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