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α‐Glucosidase Inhibitory Xanthones from the Roots of Garcinia fusca
Authors:Nam K. Nguyen  Xuyen A. Truong  Thai Q. Bui  Dzung N. Bui  Hai X. Nguyen  Phuong T. Tran  Lien‐Hoa D. Nguyen
Affiliation:Faculty of Chemistry, VNUHCM–University of Science, Ho Chi Minh City, Vietnam
Abstract:Two new compounds, fuscaxanthones J ( 1 ) and K ( 2 ), together with eight known xanthones ( 3 – 10 ) were isolated from an ethyl acetate extract of the roots of Garcinia fusca. Their structures were determined using spectroscopic methods, mainly 1D‐ and 2D‐NMR. α‐Glucosidase inhibitory activity of the isolated compounds was evaluated and fuscaxanthone J ( 1 ) showed the most significant effect with an IC50 value of 8.3 ± 1.8 μm (compared with acarbose, IC50 = 214.5 ± 2.3 μm ).
Keywords:   Garcinia fusca     Xanthones  Fuscaxanthones J and K  α  ‐Glucosidase inhibitory activity
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