Structural Modification of Stilbenoids from Acanthopanax leucorrhizus and Their Cytotoxic Activity |
| |
| Authors: | Hao‐Bin Hu Hai‐Peng Liang Hai‐Ming Li Ru‐Nan Yuan Jiao Sun Yun Wu La‐La Zhang Ming‐Hu Han |
| |
| Affiliation: | 1. College of Chemistry & Chemical Engineering, Longdong University, Qingyang, P. R. China;2. Department of Oncology, Qingyang First People's Hospital, Qingyang, P. R. China;3. College of Food Science and Engineering, Gansu Agricultural University, Lanzhou, P. R. China |
| |
| Abstract: | A new cis‐stilbenoid, 1,9‐dihydroxy‐10‐methoxy‐6H‐dibenzo[b,f]oxocin‐6‐one ( 2 ) was isolated from the AcOEt extract of the stem barks of Acanthopanax leucorrhizus, along with three known stilbenoids, 9‐hydroxy‐10‐methoxy‐6H‐dibenzo[b,f]oxocin‐6‐one ( 1 ), 5‐O‐methyl‐(E)‐resveratrol 3‐O‐β‐d ‐glucopyranoside ( 3 ), and (E)‐resveratrol 3‐O‐β‐d ‐xylopyranoside ( 4 ). Two derivatives ( 2a and 2b ) were synthesized by the structural modification of compound 2, which exhibited certain cytotoxic activities against HT‐29 and HeLa cell lines in vitro. All compounds were structurally characterized by comprehensive analysis of their spectroscopic data and comparison with literature information, and evaluated for their cytotoxic activities against three human tumor cell lines (HL‐60, HT‐29, and HeLa) by the standard MTT assay in vitro. The results showed that derivatives 2a and 2b exhibited strong activities than compounds 2 against HT‐29 and HeLa cell lines. |
| |
| Keywords: |
Acanthopanax leucorrhizus
Stilbenoids Isolation Structural modification Cytotoxic activity |
|
|
