Phytochemical Study of the Genus Salpichroa (Solanaceae), Chemotaxonomic Considerations,and Biological Evaluation in Prostate and Breast Cancer Cells |
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Authors: | Ana Valentina Basso Segundo Leiva González Gloria Estela Barboza Valeria Pilar Careaga Juan Carlos Calvo Paula A. Sacca Viviana Estela Nicotra |
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Affiliation: | 1. Facultad de Ciencias Químicas, Instituto Multidisciplinario de Biología Vegetal (IMBIV‐CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina;2. Museo de Historia Natural, Universidad Privada Antenor Orrego, Trujillo, Perú;3. Departamento de Química Orgánica, Unidad de Microanálisis y Métodos Físicos Aplicados a la Química Orgánica (UMYMFOR‐CONICET), Facultad de Ciencias, Exactas y Naturales, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina;4. Instituto de Biología y Medicina Experimental (IBYME‐CONICET), Ciudad Autónoma de Buenos Aires, Argentina |
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Abstract: | Twelve Salpichroa taxa have been phytochemically analyzed. From the aerial parts of S. scandens, four known salpichrolides A, C, I, S, and an unreported withanolide named salpichrolide V ( 1 ), were isolated. In S. dependens, S. gayi, S. glandulosa subsp. glandulosa, S. glandulosa subps. weddellii, S. leucantha, S. micrantha, S. microloba, S. proboscidea, S. ramosissima, S. tristis var. tristis, and S. weberbauerii, no withanolides were found. The chemical content of ca. 85% of the Salpichroa taxa is in agreement with molecular studies, which suggest that Salpichroa and Jaborosa, a genus considered morphologically close to Salpichroa, are distant in the systematic of the Solanoideae subfamily. Moreover, the in vitro cytotoxic activity of a set of natural salpichrolides and derivatives was examined against two prostate carcinoma cell lines (PC3 and LNCaP) and two human breast cancer cell lines (MCF‐7 and T47D). Several compounds showed moderate activity (IC50 = 64.91 – 29.97 μm ). |
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Keywords: |
Salpichroa
Withanolides Structure elucidation Chemotaxonomic markers Cytotoxic activities |
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