Novel Flavones from the Root of Phytolacca acinosa Roxb. |
| |
| Authors: | Xiao‐Pan Ma Wen‐Fang Zhang Ping Yi Jun‐Jie Lan Bin Xia Sai Jiang Hua‐Yong Lou Wei‐Dong Pan |
| |
| Institution: | 1. College of Pharmacy, Zunyi Medical College, Zunyi, P. R. China;2. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, P. R. China;3. The Key Laboratory of Chemistry for Natural Products of Guizhou Province, Chinese Academy of Sciences, Guiyang, P. R. China;4. The Fourth People's Hospital of Zunyi, Zunyi, P. R. China |
| |
| Abstract: | Two new flavones, 6,7‐methylenedioxy‐4‐hydroxypeltogynan‐7′‐one ( 1 ), cochliophilin B ( 2 ), as well as two known ones, cochliophilin A ( 3 ) and 6‐methoxy‐7‐hydroxy flavone ( 4 ), were isolated from the ethanol extract of the root of Phytolacca acinosa Roxb . Compound 1 is a flavanol framework with one δ‐lactone unit, which is rather rare in nature. The structures of the new compounds were determined on the basis of extensive spectroscopic (IR, MS, 1D‐ and 2D‐NMR) analyses, the absolute configuration of 1 was established by comparing experimental and calculated electronic circular dichroism spectra. The structures of known compounds were fixed by comparison with literatures data. Compounds 2 and 4 showed modest inhibitory activities against BEL‐7402 cell line, with IC50 values of 28.22 and 39.16 μmol/L, respectively. |
| |
| Keywords: | Phytolacca acinosa Roxb 6 7‐methylenedioxy‐4‐hydroxypeltogynan‐7′ ‐one flavone cochliophilin B cytotoxic activity |
|
|
