A New Anti‐Inflammatory Alkaloid from Roots of Heracleum dissectum |
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| Authors: | Hai‐Long Zhang Xin‐Yuan Wu Jie Mi Ya‐Jie Peng Zhi‐Gang Wang Ying Liu Xiu‐Li Wu Yang Gao |
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| Affiliation: | 1. School of Pharmacy, Xi'an Jiaotong University, Xi'an, P. R. China;2. College of Pharmacy, Ningxia Medical University, Yinchuan, P. R. China;3. Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, P. R. China;4. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, P. R. China |
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| Abstract: | Using various chromatographic methods, a new piperidinone alkaloid, (3S)‐3‐{4‐[(1E)‐3‐hydroxyprop‐1‐en‐1‐yl]‐2‐methoxyphenoxy}piperidin‐2‐one ( 1 ), together with 10 known compounds, bergapten ( 2 ), xanthotoxol ( 3 ), isopimpinellin ( 4 ), isobergapten ( 5 ), heratomol‐6‐O‐β‐d ‐glucopyranoside ( 6 ), scopoletin ( 7 ), apterin ( 8 ), 3‐methoxy‐4‐β‐d ‐glucopyranosyloxypropiophenone, (praeroside; 9 ), tachioside ( 10 ) and coniferin ( 11 ), were isolated from roots of Heracleum dissectum Ledeb . Their structures were elucidated on the basis of physicochemical properties and the detailed interpretation of various spectroscopic data. All the isolated compounds were screened for anti‐inflammatory activity in vitro. As the results, compound 1 and 8 showed significantly inhibitory activity on nitric oxide production in RAW264.7 cells. |
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| Keywords: |
Heracleum dissectum
Ethnic herbs Alkaloids Structure elucidation Anti‐inflammation |
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