Cytotoxic and Antimicrobial Activity of Dehydrozingerone based Cyclopropyl Derivatives |
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| Authors: | Adrijana Z. Burmudžija Jovana M. Muškinja Marijana M. Kosanić Branislav R. Ranković Slađana B. Novaković Snežana B. Đorđević Tatjana P. Stanojković Dejan D. Baskić Zoran R. Ratković |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science, University of Kragujevac, Kragujevac, Serbia;2. Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Kragujevac, Serbia;3. Vin?a Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia;4. National Poison Control Centre, Military Medical Academy, Belgrade, Serbia;5. Institute of Oncology and Radiology of Serbia, Belgrade, Serbia;6. Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia;7. Public Health Institute Kragujevac, Nikole Pa?i?a 1, Kragujevac, Serbia |
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| Abstract: | A small series of 1‐acetyl‐2‐(4‐alkoxy‐3‐methoxyphenyl)cyclopropanes was prepared, starting from dehydrozingerone (4‐(4‐hydroxy‐3‐methoxyphenyl)‐3‐buten‐2‐one) and its O‐alkyl derivatives. Their microbiological activities toward some strains of bacteria and fungi were tested, as well as their in vitro cytotoxic activity against some cancer cell lines (HeLa, LS174 and A549). All synthesized compounds showed significant antimicrobial activity and expressed cytotoxic activity against tested carcinoma cell lines, but they showed no significant influence on normal cell line (MRC5). Butyl derivative is the most active on HeLa cells (IC50 = 8.63 μm ), while benzyl one is active against LS174 and A549 cell lines (IC50 = 10.17 and 12.15 μm , respectively). |
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| Keywords: | Cytotoxic activities Antimicrobial activities Dehydrozingerone Cyclopropyl moiety Crystal structure elucidation |
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