New Cytotoxic Alkylated Chalcones from Fatoua villosa |
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| Authors: | Shi‐Yun Su Jing‐Jing Xue Guang‐Yu Yang Chun Lei Ai‐Jun Hou |
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| Affiliation: | 1. Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, P. R. China;2. Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd., Kunming, P. R. China |
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| Abstract: | Three new alkylated chalcones, villosins A – C ( 1 – 3 ), five known analogues, together with ten known coumarins, were isolated from Fatoua villosa. The structures of the new compounds were elucidated by extensive spectroscopic analysis, including 1D‐, 2D‐NMR, and MS data. Compounds 1 – 3 showed cytotoxicity against five kinds of human tumor cell lines (NB4, A549, SHSY5Y, PC3, and MCF7) with IC50 values ranging from 1.4 ± 0.1 to 5.7 ± 0.3 μm . |
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| Keywords: |
Fatoua villosa
Alkylated chalcone Cytotoxic activities Villosin Coumarin |
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