Protostane‐Type Triterpenoids from Alisma orientale |
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| Authors: | Hong‐Mei Li Xue‐Jiao Chen Dan Luo Min Fan Zhi‐Jun Zhang Li‐Yan Peng Xing‐De Wu Rong‐Tao Li Xu Ji Qin‐Shi Zhao |
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| Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China;2. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, P. R. China |
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| Abstract: | Twenty‐eight protostane triterpenoids, including a new degraded one ( 1 ), nine new ones ( 2 – 10 ), and two new natural ones ( 11 and 12 ), have been isolated from the dried rhizomes of Alisma orientale. Alisol R ( 1 ) was the first 20,21,22,23,24,25,26,27‐octanorprotostane triterpenoid. The absolute configurations of 25‐methoxyalisol F ( 2 ) and 16β‐hydroperoxyalisol B 23‐acetate ( 3 ) were determined by X‐ray diffraction analysis. In addition, alismaketone‐B 23‐acetate ( 28 ) showed potent vasorelaxant activity on endothelium‐intact thoracic aorta rings precontracted with KCl. |
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| Keywords: |
Alisma orientale
Alismatis Rhizoma Alismataceae Protostane triterpenoids Vasorelaxant activity |
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