2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole analogues: Antifungal activity in vitro against <Emphasis Type="Italic">Candida</Emphasis> species |
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Authors: | J Matysiak Z Malinski |
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Institution: | (1) Department of Chemistry, Agricultural University, Akademicka 15, 20-950 Lublin, Poland;(2) Institute of Industrial Organic Chemistry, Annopol 6, 03-236 Warszawa, Poland |
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Abstract: | The antifungal activity in vitro of the newly synthesized and previously reported compounds of 5-substituted 2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole series was evaluated. Their structures were confirmed by elemental analyses and IR, 1H and 13C NMR and mass spectra. The azole-resistant clinical isolates of Candida albicans and no-albicans Candida spp. were used in the antifungal tests. Some compounds exhibit higher activities than the comparatively studied antifungal drugs. Amino-1,3,4-thiadiazole derivatives exhibited higher (than other analogues) antifungal effects against Candida no-albicans spp. than against C. albicans. Derivatives with strong antifungal activity have a narrow range of lipophilicity values determined by the Villar approach. |
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Keywords: | antifungal activity Candida species 2-(2 4-dihydroxyphenyl)-1 3 4-thiadiazoles in vitro studies lipophilicity |
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