Regulatory T cells in skeletal muscle repair and regeneration: recent insights |
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| Authors: | Jianhui Wu Bowen Ren Daochao Wang Hui Lin |
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| Affiliation: | 1.Cancer Center, Beijing LuHe Hospital, Capital Medical University, Beijing, 101149 China ;2.Jiangxi Province Key Laboratory of Tumor Pathogens and Molecular Pathology and Department of Pathophysiology, School of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi China ;3.Chinese PLA Medical School, Beijing, 100853 China |
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| Abstract: | Skeletal muscle repair and regeneration after injury is a multi-stage process, involving a dynamic inflammatory microenvironment consisting of a complex network formed by the interaction of immune cells and their secreted cytokines. The homeostasis of the inflammatory microenvironment determines whether skeletal muscle repair tissues will ultimately form scar tissue or regenerative tissue. Regulatory T cells (Tregs) regulate homeostasis within the immune system and self-immune tolerance, and play a crucial role in skeletal muscle repair and regeneration. Dysregulated Tregs function leads to abnormal repair. In this review, we discuss the role and mechanisms of Tregs in skeletal muscle repair and regeneration after injury and provide new strategies for Treg immunotherapy in skeletal muscle diseases.Subject terms: Trauma, Immunotherapy |
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