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GPI-anchor synthesis: Ras takes charge
Authors:Hancock John F
Affiliation:Institute for Molecular Bioscience, University of Queensland Brisbane 4072, Australia.
Abstract:A new study shows that Ras2 regulates GPI-anchor synthesis in the ER. Reciprocally, the targeted enzyme GPI-GlcNAc transferase regulates Ras2 signal output. This novel intersection of Ras2 signaling and an ER-localized protein complex has interesting implications for Ras function.
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