溶栓胶囊联合丁苯酞软胶囊对脑梗死恢复期患者血液流变学、脑血流动力学和神经因子的影响

摘要 目的：探讨溶栓胶囊联合丁苯酞软胶囊对脑梗死恢复期患者血液流变学、脑血流动力学和神经因子的影响。方法：选取2021年1月-2022年1月期间长治医学院附属和平医院收治的100例脑梗死恢复期患者，按照随机数字表法分为研究组（50例）和对照组（50例），对照组接受丁苯酞软胶囊治疗，研究组接受溶栓胶囊联合丁苯酞软胶囊治疗。对比两组疗效、血液流变学、脑血流动力学、神经因子和不良反应发生情况。结果：研究组90.00%的临床总有效率高于对照组72.00%（P<0.05）。治疗20 d后，两组美国国立卫生院神经功能缺损评分（NIHSS）评分下降，Barthel指数（BI）评分升高，且研究组改善幅度大于对照组（P<0.05）。治疗20 d后，两组全血粘度、血浆粘度、血沉（ESR）、纤维蛋白原（FIB）和红细胞压积（HCT）均下降，且研究组低于对照组（P<0.05）。治疗20 d后，两组平均血流速度（Vm）升高，搏动指数（PI）及阻力指数（RI）均下降，且研究组改善幅度大于对照组（P<0.05）。治疗20 d后，两组神经元特异性烯醇化酶（NSE）下降，神经生长因子（NGF）、神经营养因子（BDNF）升高，且研究组改善幅度大于对照组（P<0.05）。两组不良反应发生率组间对比无差异（P>0.05）。结论：溶栓胶囊联合丁苯酞软胶囊可有效改善脑梗死恢复期患者血液流变学、脑血流动力学，促进神经功能恢复，提高生活活动能力，效果显著。

Effects of Thrombolytic Capsule Combined with Butylphthalide Soft Capsule on Hemorheology, Cerebral Hemodynamics and Nerve Factors in Patients with Cerebral Infarction in the Recovery Period

ABSTRACT Objective: To explore the effect of thrombolytic capsule combined with butylphthalide soft capsule on hemorheology, cerebral hemodynamics and nerve factors in patients with cerebral infarction in the recovery period. Methods: 100 patients with cerebral infarction in the recovery period admitted to Heping Hospital Affiliated to Changzhi Medical College from January 2021 to January 2022 were divided into the study group (n=50) and the control group (n=50) according to the random number table method.The control group received treatment with butylphthalide soft capsules, while the study group received treatment with thrombolytic capsules combined with butylphthalide soft capsules. The curative effect, hemorheology, cerebral hemodynamics, nerve factors and adverse reactions of the two groups were compared. Results: The clinical total effective rate of 90.00% in the study group was higher than 72.00% in the control group (P<0.05). After 20 days of treatment, the National Institutes of Health Neurological Impairment Scale (NIHSS) score decreased and the Barthel Index (BI) score increased in both groups, and the improvement in the study group was greater than that in the control group (P<0.05). After 20 days of treatment, the whole blood viscosity, plasma viscosity, erythrocyte sedimentation rate (ESR), fibrinogen (FIB), and hematocrit (HCT) of both groups decreased, and the study group was lower than the control group (P<0.05). After 20 days of treatment, the average blood flow velocity (Vm) increased, while the pulsatile index (PI) and resistance index (RI) decreased in both groups, and the improvement in the study group was greater than that in the control group (P<0.05). After 20 days of treatment, neuron specific enolase (NSE) decreased, nerve growth factor (NGF) and neurotrophin (BDNF) increased in both groups, and the improvement in the study group was greater than that in the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Thrombolytic capsule combined with butylphthalide soft capsule can effectively improve the hemorheology and cerebral hemodynamics of patients with cerebral infarction in the recovery period, promote the recovery of neural function, and improve the ability of life activities. The effect is significant.