Metabolism of lysine in rat liver |
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| Authors: | K Higashino M Fujioka T Aoki T Yamamura |
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| Affiliation: | 1. Third Department of Internal Medicine Osaka University Medical School, Osaka, Japan;2. Department of Biochemistry Osaka University Medical School, Osaka, Japan;1. Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA;1. Department of Lifescience and Biotechnology, College of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, PR China;2. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China;3. Key Laboratory of Algal Biology, Institute of Hydrobiology, The Chinese Academy of Sciences, Wuhan 430072, PR China;1. Department of General Surgery, Microinvasive Liver and Pancreas Surgery Unit, First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning, China;2. Grade 12 Class 8, Liaoning Medical University, Jinzhou, Liaoning, China |
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| Abstract: | It was shown previously that lysine was degraded in the mitochondria in the presence of α-ketoglutarate and, under these conditions, saccharopine accumulated (1). The obligatory requirement of α-ketoglutarate for lysine breakdown as well as for saccharopine formation suggest that lysine is metabolized, in mammalian liver, by a reversal of reaction sequence described for its biosynthesis in yeast (2–6).The present report describes that saccharopine is further metabolized to α-aminoadipic acid in the mitochondria and that NAD rather than NADP is required in this reaction. |
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