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The effect of polyamines on tyrosine hydroxylase and L-Aromatic amino acid decarboxylase |
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| Authors: | A S Walters Dr L J Côté A S Perumal L T Kremzner |
| Institution: | (1) Departments of Rehabilitation Medicine and Neurology College of Physicians and Surgeons, Columbia University, 10032 New York, New York;(2) New York State Psychiatric Institute, 10032 New York, New York;(3) Present address: College of physicians and Surgeons, Columbia University, 640 W. 168th St., 10032 New York, NY |
| Abstract: | The polyamines stimulated tyrosine hydroxylase in whole homogenates of bovine caudate nuclei approximately 2 fold. TheV max forl-tyrosine increased by 2.3 fold while theK m s forl-tyrosine and for the cofactor (DMPH4) were unchanged.l-Aromatic amino acid decarboxylase from whole rat brain homogenate was stimulated by about 40% in the presence of polyamines. These findings suggest that increased polyamine levels associated with increased cellular synthetic activity can modify the synthesis of neurotransmitters. |
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