|
|||||
|
|
The effect of polyamines on tyrosine hydroxylase and L-Aromatic amino acid decarboxylase |
|
| Authors: | A. S. Walters Dr. L. J. Côté A. S. Perumal L. T. Kremzner |
| Affiliation: | (1) Departments of Rehabilitation Medicine and Neurology College of Physicians and Surgeons, Columbia University, 10032 New York, New York;(2) New York State Psychiatric Institute, 10032 New York, New York;(3) Present address: College of physicians and Surgeons, Columbia University, 640 W. 168th St., 10032 New York, NY |
| Abstract: | The polyamines stimulated tyrosine hydroxylase in whole homogenates of bovine caudate nuclei approximately 2 fold. TheVmax forl-tyrosine increased by 2.3 fold while theKms forl-tyrosine and for the cofactor (DMPH4) were unchanged.l-Aromatic amino acid decarboxylase from whole rat brain homogenate was stimulated by about 40% in the presence of polyamines. These findings suggest that increased polyamine levels associated with increased cellular synthetic activity can modify the synthesis of neurotransmitters. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |