ENZYMES OF PHOSPHOINOSITIDE METABOLISM DURING RAT BRAIN DEVELOPMENT |
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Authors: | J. G. Salway J. L. Harwood M. Kai G. L. White J. N. Hawthorne |
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Affiliation: | Department of Medical Biochemistry and Pharmacology, University of Birmingham, England |
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Abstract: | —The activities of four enzymes concerned with inositol lipid metabolism have been determined in homogenates of rat brains of different ages. The enzymes are CDP-diglyceride inositol phosphatidate transferase, phosphatidylinositol kinase, diphosphoinositide kinase and triphosphoinositide phosphomonoesterase. The activities of all the enzymes increased with age. Phosphatidylinositol kinase activity rose most sharply well before myelination, reaching a maximum at about 6 days of age. Diphosphoinositide kinase and triphosphoinositide phosphomonoesterase activities increased most rapidly during myelination. The increase in CDP-diglyceride inositol phosphatidate transferase showed no definite association with any period of development. It is concluded that triphosphoinositide metabolism is associated with myelin or a closely related structure. |
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