Nanoparticle-mediated double-stranded RNA delivery system: A promising approach for sustainable pest management |
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| Authors: | Shuo Yan Bin-Yuan Ren Jie Shen |
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| Institution: | 1. Department of Entomology and MOA Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing, China;2. National Agricultural Technology Extension and Service Center, Beijing, China |
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| Abstract: | RNA interference (RNAi) targeting lethal genes in insects has great potential for sustainable crop protection. Compared with traditional double-stranded (ds)RNA delivery systems, nanoparticles such as chitosan, liposomes, and cationic dendrimers offer advantages in delivering dsRNA/small interfering (si)RNA to improve RNAi efficiency, thus promoting the development and practice of RNAi-based pest management strategies. Here, we illustrate the limitations of traditional dsRNA delivery systems, reveal the mechanism of nanoparticle-mediated RNAi, summarize the recent progress and successful applications of nanoparticle-mediated RNAi in pest management, and finally address the prospects of nanoparticle-based RNA pesticides. |
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| Keywords: | dsRNA delivery nanocarrier pest control RNAi efficiency RNA pesticide |
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