Oligonucleotide labeling using BODIPY phosphoramidite |
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Authors: | Tram Kha Twohig Daniel Yan Hongbin |
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Institution: | Department of Chemistry, Brock University, St. Catharines, Ontario, Canada. |
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Abstract: | 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) derivatives were prepared and their photochemical properties were characterized. One such analogue, 4,4-difluoro-4-bora-1,3,5,7-tetramethyl-8-(5-hydroxypentyl)-3a,4a-diaza-s-indacene was transformed into the corresponding phosphoramidite and incorporated into oligodeoxyribonucleotides as a fluorescent reporter group. |
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