Alpha-synuclein and the pathogenesis of Parkinson's disease |
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| Authors: | Martin Francis L Williamson Sally J M Paleologou Katerina E Allsop David El-Agnaf Omar M A |
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| Institution: | Department of Biological Sciences, I.E.N.S., Lancaster University, Lancaster LA1 4YQ, UK. |
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| Abstract: | Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinson's disease (PD) patients. Intracellular aggregation of alpha-synuclein (alpha-syn) appears to play a key role in the generation of LBs and LNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks. |
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