Apoptosis induced by picolinic acid-related compounds in HL-60 cells. |
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| Authors: | S Ogata K Inoue K Iwata K Okumura H Taguchi |
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| Affiliation: | Department of Life Science, Faculty of Bioresources, Mie University, Tsu, Japan. |
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| Abstract: | We have found that niacin-related compounds, particularly picolinic acid, induced apoptosis in human leukemia cells. In this paper, we investigated whether various picolinic acid-related compounds had apoptosis-inducing activities or not. Particularly, fusaric acid, picolinaldehyde, nicotinaldehyde, 2-aminopyridine, and 3-aminopyridine also induced apoptosis in HL-60 cells. These results suggest that pyridine substituted with various groups and the consequent change of resonance structure may have an important role in the induction of apoptosis. |
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