Therapeutic Effects of Suppressors of Cytokine Signaling in Diabetic Nephropathy |
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| Authors: | Qingjuan Liu Lingling Xing Lei Wang Fang Yao Shuxia Liu Jun Hao Wei Liu Huijun Duan |
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| Institution: | Department of Pathology (QL, FY, SL, JH, WL, HD), Hebei Medical University, Shijiazhuang, China;Department of Anatomy (LW), Hebei Medical University, Shijiazhuang, China;Department of Nephrology (LX), Second Affiliated Hospital of Hebei Medical University, Shijiazhuang, China |
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| Abstract: | Inflammation is an important pathophysiological mechanism in diabetic nephropathy (DN). Tubular epithelial cell-myofibroblast transdifferentiation (TEMT), which can be induced by many cytokines, is an important event in DN. Oncostatin M (OSM), an inflammatory cytokine, can induce TEMT in vitro. The suppressors of cytokine signaling (SOCS) proteins are negative-feedback regulators of cytokine signaling. The purpose of this study was to investigate the role of SOCS in DN. The results demonstrated that overexpression of SOCS ameliorated proteinuria, the expression of α-SMA and OSM in tubular epithelial cells, and interstitial extracellular matrix accumulation in the renal tissue of CD-1 mice. In addition, our previous studies indicated that OSM induced TEMT by activating the JAK/STAT pathway, which could be inhibited by SOCS. These results indicate that overexpression of SOCS has a therapeutic effect in DN. |
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| Keywords: | diabetic nephropathy epithelial-myofibroblast transdifferentiation oncostatin M SOCS |
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