Protection from murine cysticercosis by immunization with a parasite cysteine protease |
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Authors: | Baig Salman Damian Raymond T Morales-Montor Jorge Ghaleb Amr Baghdadi Amjed White A Clinton |
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Institution: | Department of Cellular Biology, University of Georgia, Biological Sciences Building, Athens, GA 30603, USA. |
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Abstract: | Central nervous system infection by Taenia solium cysts causes neurocysticercosis, a common neurological infection in the Third World. We have previously isolated cysteine proteases from Taenia crassiceps and T. solium. In this study, we immunized BALB/c mice with the purified T. solium cysteine protease and challenged them with Taenia crassiceps. Immunized mice had a 72% reduction in parasite burden compared to mice that received no immunization. Immunized mice developed antigen specific lymphocyte proliferation. These data support further studies of the T. solium cysteine protease as a vaccine candidate. |
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