|
|||||
|
|
Application of mesenchymal stem cells in regenerative medicine: A new approach in modern medical science |
|
| Authors: | Faezeh Ebrahimi Farzaneh Pirouzmand Renzon Daniel Cosme Pecho Mariam Alwan Mohammed Yassen Mohamed Mohammed Shnain Ali Arezoo Hormozi Sajedeh Hasanzadeh Narges Daei Zahra Hajimortezayi Majid Zamani |
| Affiliation: | 1. Medical Laboratory, Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran Contribution: Conceptualization (equal), Writing - original draft (equal);2. Infectious Diseases Research Center, Gonabad University of Medical Sciences, Gonabad, Iran Contribution: Conceptualization (equal), Writing - original draft (equal);3. Department of Biochemistry, Universidad San Ignacio de Loyola (USIL), Lima, Peru Contribution: Conceptualization (equal), Writing - review & editing (equal);4. Medical Technical College, Al-Farahidi University, Baghdad, Iraq Contribution: Conceptualization (equal), Writing - review & editing (equal);5. Department of Anesthesia Techniques, AlNoor University College, Nineveh, Iraq Contribution: Conceptualization (equal), Writing - review & editing (equal);6. Department of Dentistry, Al-Zahrawi University College, Karbala, Iraq Contribution: Conceptualization (equal), Writing - review & editing (equal);7. Medical Laboratory, Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran Contribution: Investigation (equal), Writing - original draft (equal);8. Medical Laboratory, Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran Contribution: Conceptualization (equal), Investigation (equal), Writing - original draft (equal);9. Medical Laboratory, Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran Contribution: Conceptualization (equal), Investigation (equal), Writing - review & editing (equal);10. Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran |
| Abstract: | Mesenchymal Stem Cells (MSCs) are non-hematopoietic and multipotent stem cells, which have been considered in regenerative medicine. These cells are easily separated from different sources, such as bone marrow (BM), umbilical cord (UC), adipose tissue (AT), and etc. MSCs have the differentiation capability into chondrocytes, osteocytes, and adipocytes; This differentiation potential along with the paracrine properties have made them a key choice for tissue repair. MSCs also have various advantages over other stem cells, which is why they have been extensively studied in recent years. The effectiveness of MSCs-based therapies depend on several factors, including differentiation status at the time of use, concentration per injection, delivery method, the used vehicle, and the nature and extent of the damage. Although, MSCs have emerged promising sources for regenerative medicine, there are potential risks regarding their safety in their clinical use, including tumorigenesis, lack of availability, aging, and sensitivity to toxic environments. In this study, we aimed to discuss how MSCs may be useful in treating defects and diseases. To this aim, we will review recent advances of MSCs action mechanisms in regenerative medicine, as well as the most recent clinical trials. We will also have a brief overview of MSCs resources, differences between their sources, culture conditions, extraction methods, and clinical application of MSCs in various fields of regenerative medicine. |
| Keywords: | cell therapy mesenchymal stem cell regenerative medicine self-renewal tissue repair |