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1H-NMR studies on substance P hexapeptide analogs |
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| Authors: | Anthony Ribeiro Oleg Jardetzky Chaim Gilon Dina Teitelbaum Michael Chorev |
| Abstract: | 1H-nmr studies of pGlu6]SP6–11, gpGlu6,mPhe7]SP6–11, and pGlu6,N-CH3Phe7]SP6–11 in DMSO-d6 reveal characteristic chemical shifts, 3JNH-αCH, temperature dependence, as well as deuterium exchange half-times. Marked similarities are revealed for the two first analogs, whereas the N-methylated analog is clearly different. Possible conformations are considered. |
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