Conformational and functional properties of hemoglobin in water–organic cosolvent mixtures: Effect of ethylene glycol and glycerol on oxygen affinity |
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Authors: | Donatella Bulone Antonio Cupane Lorenzo Cordone |
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Abstract: | We report on the effects that the presence of ethylene glycol or glycerol has on the oxygen affinity of hemoglobin. We attribute these effects to an altered equilibrium between T and R quaternary conformations of hemoglobin and separate them into bulk-electrostatic and non-bulk-electrostatic contributions to the standard free-energy difference between the R and T states. |
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