Novel ether derivatives of mannopeptimycin glycopeptide antibiotic |
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Authors: | Sum Phaik-Eng How David Torres Nancy Petersen Peter J Lenoy Eileen B Weiss William J Mansour Tarek S |
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Institution: | Department of Chemical Sciences, Wyeth Research, Chemical Sciences Building 222/Room 3147, 401N. Middleton Road, Pearl River, New York, NY 10965, USA. sump@wyeth.com |
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Abstract: | Novel ether derivatives of mannopeptimycin glycopeptide were synthesized to probe their SAR. Many of these derivatives exhibited potent antibacterial activity against methicillin resistant and vancomycin resistant strains. These ether derivatives were prepared via reductive ring cleavage of acetals to give a mixture of 6-O, 4-O, 3-O, and 2-O-ether isomers. Both 6-O-ether and 4-O-ether showed significantly enhanced antibacterial activity over the parent and the isovalerate esters. |
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