Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4 |
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| Authors: | Hammermann R Brunn G Racké K |
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| Institution: | Institute of Pharmacology and Toxicology, Rheinische Friedrich-Wilhelms-Universit?t, Bonn, Federal Republic of Germany. r.hammermann@uni-bonn.de |
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| Abstract: | Summary. By screening nucleotide databases, sequences containing the complete genes of the human cationic amino acid transporters
(hCATs) 1, 2 and 4 were identified. Analysis of the genomic organization revealed that hCAT-2 consists of 12 translated exons
and most likely of 2 untranslated exons. The splice variants hCAT-2A and hCAT-2B use exon 7 and 6, respectively. The hCAT-2
gene structure is closely related to the structure of hCAT-1, suggesting that they belong to a common gene family. hCAT-4
consists of only 4 translated exons and 3 short introns. Exons of identical size and highly homologous to exon 3 of hCAT-4
are present in hCAT-1 and hCAT-2.
Received September 8, 2000 Accepted January 8, 2001 |
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| Keywords: | : Cationic amino acids Human cationic amino acid transporter Solute carrier family Genomic organization Exon-intron structure |
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