Influence of high dietary threonine on growth and amino acids in blood and tissues of rats |
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Authors: | G. Sarwar R. W. Peace H. G. Botting |
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Affiliation: | (1) Health Protection Branch, Food Directorate, Banting Building, Tunney's Pasture, Health and Welfare Canada, K1A OL2 Ottawa, Ontario, Canada |
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Abstract: | Summary Diets containing 8 or 15% protein from casein plus limiting amino acids, 25% fat and adequate levels of other nutrients for rat growth were supplemented with 0, 0.5, 1.0, 2.0 or 4% of excess L-threonine. Addition of up to 1% excess threonine had little effect on weight gains or food intakes of weanling rats, but addition of 2 and 4% threonine caused a drastic reduction in weight gains or food intakes (up to 41%); the adverse effect being more severe in rats fed lower protein diets. Addition of graded levels of excess threonine resulted in (5 to 47-fold and 4 to 20-fold) increase in concentration of free threonine in rat plasma and brain, respectively. Addition of excess threonine also caused up to 5-fold increase in plasma level of 3-methylhistidine, suggesting increased muscle protein breakdown. |
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Keywords: | Amino acids Excess dietary threonine Rat growth Tissue amino acids |
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