Three new cytotoxic Diels-Alder-type adducts from Morus australis |
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| Authors: | Zhang Qing-Jian Tang Yan-Bo Chen Ruo-Yun Yu De-Quan |
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| Institution: | The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, PR China. |
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| Abstract: | Three new natural products, australisines A-C (1-3, resp.), were isolated from the stem bark of Morus australis, together with eight related compounds, including mulberrofurans E-G, J, and Q, mongolicin C, chalcomoracin, and kuwanon G. Their structures were fully characterized by spectroscopic methods. Compounds 1-3, mulberrofuran G, mongolicin C, and chalcomoracin showed moderate cytotoxic activities against five human cancer cell lines, with IC50 values ranging from 4.6-9.2 microg/ml, as determined by MTT assay. |
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| Keywords: | Morus australis Diels – Alder adducts Cytotoxic activity Australisines A – C |
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