|
|||||
|
|
Topoisomerase-II-inhibitory principles from the stems of Spatholobus suberectus |
|
| Authors: | Han Ah-Reum Park Hyen Joo Chen Daofeng Jang Dae Sik Kim Hwa-Jung Lee Sang Kook Seo Eun-Kyoung |
| Institution: | College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea. |
| Abstract: | Bioassay-guided fractionation of the stems of Spatholobus suberectus led to the isolation of procyanidin B4 (= (+)-catechin-(4-->8)-(-)-epicatechin) (1) and (+)-catechin-(4-->8)-(+)-catechin-(4-->8)-(-)-epicatechin (2). These compounds, isolated before from other sources, were found to be highly potent inhibitors of DNA-topoisomerase-II (Topo-II)-mediated KDNA decatenation, with IC50 values of 22.5+/-2.3 and 21.9+/-2.2 nM, resp. |
| Keywords: | Topoisomerase II Spatholobus suberectus Procyanidin B4 (+)‐Catechin‐(4→8)‐(+)‐catechin‐(4→8)‐(−)‐epicatechin |
| 本文献已被 PubMed 等数据库收录！ | |